HIV/AIDS患者服药依从性影响因素的Meta分析

Meta-analysis of Factors Influencing HIV/AIDS Patients'Medication Compliance

目的探讨中国HIV/AIDS患者服药依从性的影响因素,为艾滋病的预防控制提供参考依据。方法在中国知网、万方、维普、中国生物医药数据库检索2008年1月-2021年3月中文文献,在PubMed、Cochrane Library、Web of Science和EMbase数据库检索同期发表的外文文献;应用RevMan 5.3软件对纳入文献进行Meta分析。结果共检索出相关中文、英文文献995篇,根据纳入与排除标准,最终纳入文献共21篇,其中中文17篇,英文4篇,共调查人数5923例,其中4653例服药依从性较好,占总数78.56%。对纳入的影响因素进行Meta分析结果显示,不同年龄(OR=1.50,95%CI=0.95~2.38)、性别(OR=0.83,95%CI=0.70~0.98)、月收入(OR=0.72,95%CI=0.56~0.92)、文化程度(OR=0.49,95%CI=0.56~0.92)、婚姻状况(OR=1.34,95%CI=1.01~1.38)、治疗认知(OR=2.74,95%CI=1.76~4.27)、居住状况(OR=0.56,95%CI=0.29~1.06)、不良反应(OR=0.5,95%CI=0.29~0.84)、提醒服药(OR=2.78,95%CI=1.49~5.17)、饮酒(OR=0.51,95%CI=0.27~0.97)服药依从性比较,差异有统计学意义(P<0.1)。结论性别、年龄、婚姻状况、月收入、文化程度、治疗认知、居住情况、不良反应、提醒服药及饮酒是影响艾滋患者服药依从性的主要因素。

Objective To explore the factors influencing the compliance of Chinese HIV/AIDS patients with medication,and to provide a reference for the prevention and control of AIDS.Methods Searching Chinese documents in CNKI,Wanfang,Weipu,China Biomedicine Database,and foreign literature published in PubMed,Cochrane Library,Web of Science and Embase databases from January 2008 to March 2021;RevMan 5.3 software was used to conduct Meta analysis of the included literature.Results A total of 995 relevant Chinese and English documents were retrieved in this article.According to the inclusion and exclusion criteria,a total of 21 articles were finally included,including 17 in Chinese and 4 in English.A total of 5923 cases were investigated,and 4653 cases had good medication compliance,accounting for 78.56%of the total.Meta-analysis of the included influencing factors showed that different age(OR=1.50,95%CI=0.95-2.38),gender(OR=0.83,95%CI=0.70-0.98),monthly income(OR=0.72,95%CI=0.56-0.92),education level(OR=0.49,95%CI=0.56-0.92),marital status(OR=1.34,95%CI=1.01-1.38),treatment cognition(OR=2.74,95%CI=1.76-4.27),residence status(OR=0.56,95%CI=0.29-1.06),adverse reactions(OR=0.50,95%CI=0.29-0.84),remindes to take medication(OR=2.78,95%CI=1.49-5.17),drinking(OR=0.51,95%CI=0.27-0.97)medication compliance,the difference was statistically significant(P<0.1).Conclusion Gender,age,marital status,monthly income,education level,treatment cognition,living conditions,adverse reactions,reminders to take medication and drinking are the main factors affecting the compliance of AIDS patients.