氯吡格雷联合阿托伐他汀钙治疗缺血性脑卒中患者的疗效及对神经功能的影响

Efficacy of Clopidogrel Combined with Atorvastatin Calcium in the Treatment of Patients with Ischemic Stroke and its Effect on Neurological Function

目的探讨氯吡格雷联合阿托伐他汀钙治疗缺血性脑卒中(IS)患者的疗效及对神经功能的影响。方法选择2019年3月-2020年10月我院就诊的IS患者200例作为研究对象,根据随机数字表法分为药物组和对照组,每组100例。对照组应用阿托伐他汀钙片治疗,药物组在对照组基础上联合氯吡格雷治疗,比较两组临床治疗疗效、血清指标[巨噬细胞游走抑制因子(MIF)、趋化素样因子1(CKLF1)、不规则趋化因子(FKN)水平]、氧化应激指标[过氧化氢酶(CAT)、丙二醛(MDA)]、神经功能及不良反应发生情况。结果药物组临床治疗总有效率为95.00%,高于对照组的78.00%,差异有统计学意义(P<0.05);药物组MIF、CKLF1、FKN水平低于对照组,差异有统计学意义(P<0.05);药物组CAT水平高于对照组,MDA水平低于对照组,差异有统计学意义(P<0.05);药物组轻度神经功能缺损占比高于对照组,差异有统计学意义(P<0.05);药物组不良反应发生率为9.00%,与对照组的8.00%比较,差异无统计学意义(P>0.05)。结论氯吡格雷联合阿托伐他汀钙治疗IS患者疗效确切,可改善机体氧化应激反应,减轻神经功能损伤,且对血清MIF、CKLF1、FKN水平影响小,用药安全性高。

Objective To investigate the efficacy of clopidogrel combined with atorvastatin calcium in the treatment of patients with ischemic stroke(IS)and the effect on neurological function.Methods A total of 200 IS patients treated in our hospital from March 2019 to October 2020 were selected as the research objects.According to the random number table method,they were divided into drug group and control group,with 100 cases in each group.The control group was treated with atorvastatin calcium tablets,and the drug group was treated with clopidogrel on the basis of the control group.To compare the clinical treatment efficacy,serum indicators[macrophage migration inhibitory factor(MIF),chemokine-like factor 1(CKLF1),irregular chemokine(FKN)],oxidative stress indicators[catalase(CAT),malondialdehyde(MDA)],nerve function and occurrence of adverse reactions.Results The total effective rate of clinical treatment in the drug group was 95.00%,which was higher than 78.00%in the control group,the difference was statistically significant(P<0.05);The levels of MIF,CKLF1 and FKN in the drug group were lower than those in the control group,the difference was statistically significant(P<0.05);The CAT level of the drug group was higher than that of the control group,and the MDA level was lower than that of the control group,the difference was statistically significant(P<0.05);The proportion of mild neurological deficits in the drug group was higher than that in the control group,the difference was statistically significant(P<0.05);The incidence of adverse reactions in the drug group was 9.00%,which was not statistically significant compared with 8.00%in the control group(P>0.05).Conclusion Clopidogrel combined with atorvastatin calcium is effective in treating IS patients.It can improve the body's oxidative stress response,reduce nerve function damage,and has little effect on serum MIF,CKLF1,FKN levels,and has high drug safety.