降钙素联合阿仑膦酸盐治疗原发性骨质疏松症有效性评价

Evaluation of the Effectiveness of Calcitonin Combined with Alendronate Sodium in the Treatment of Primary Osteoporosis

目的观察降钙素联合阿仑膦酸盐治疗原发性骨质疏松症有效性。方法选取2017年5月-2020年5月在我院诊治的66例原发性骨质疏松症患者为研究对象,采用随机数字表法分为对照组和观察组,各33例。对照组采用阿仑膦酸盐治疗,观察组在对照组基础上联合降钙素治疗。比较两组治疗总有效率、临床症状评分、骨密度、Oswestry功能障碍指数、不良反应发生情况。结果观察组治疗总有效率为93.93%,高于对照组的81.81%,差异有统计学意义(P<0.05);治疗后,观察组步履艰难、下肢痿弱、腰膝酸软、腰脊刺痛评分均低于对照组,差异有统计学意义(P<0.05);治疗后两组腰椎正位(L2~4)、右股骨颈骨密度均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后两组Oswestry功能障碍指数均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为6.06%,与对照组的9.09%比较,差异无统计学意义(P>0.05)。结论降钙素联合阿仑膦酸盐治疗原发性骨质疏松症确切有效,可提高临床治疗总有效率,改善临床症状,提高骨密度,降低功能障碍评分,促进功能恢复,且不良反应少,临床应用安全性良好。

Objective To observe the effectiveness of calcitonin combined with alendronate sodium in the treatment of primary osteoporosis.Methods 66 patients with primary osteoporosis who were diagnosed and treated in our hospital from May 2017 to May 2020 were selected as the research objects.They were divided into control group and observation group by random number table method,with 33 cases in each group.The control group was treated with alendronate sodium,and the observation group was treated with calcitonin on the basis of the control group.The total effective rate of clinical treatment,clinical symptom score,bone mineral density,Oswestry dysfunction index,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.93%,which was higher than 81.81%in the control group,the difference was statistically significant(P<0.05);After treatment,the observation group's difficult walking,weak lower limbs,waist and knee soreness,and lumbar spine tingling scores were all lower than those of the control group,the difference was statistically significant(P<0.05);After treatment,the bone mineral density of the lumbar spine(L2-4)and the right femoral neck of the two groups were higher than before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05);After treatment,the Oswestry dysfunction index of the two groups was lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);The incidence of adverse reactions in the observation group was 6.06%compared with 9.09%in the control group,the difference was not statistically significant(P>0.05).Conclusion Calcitonin combined with alendronate sodium is definitely effective in treating primary osteoporosis.It can increase the total effective rate of clinical treatment,improve clinical symptoms,increase bone density,reduce dysfunction scores,promote functional recovery,and have fewer adverse reactions and good clinical application safety.