维生素D佐治特发性荨麻疹患者的效果及对其T淋巴细胞亚群、体液免疫水平的影响

Effects of Vitamin D on T Lymphocyte Subsets and Humoral Immune Levels in Patients with Idiopathic Urticaria

目的观察维生素D佐治特发性荨麻疹患者的效果,并探讨对其T淋巴细胞亚群、体液免疫水平的影响。方法对84例特发性荨麻疹患者的资料展开回顾,根据治疗方式分组,其中有41例仅接受常规治疗,记为A组;余43例接受维生素D辅助常规治疗,记为B组。对比症状评分、临床疗效、治疗前后T淋巴细胞亚群及体液免疫水平改变、不良反应。结果2组2周后、治疗后症状评分均低于治疗前,2组治疗后症状评分均低于2周后,B组2周后和治疗后症状评分均低于A组,差异均有统计学意义(P<0.05);2组临床疗效分布对比差异有统计学意义(P<0.05),总有效率B组高于A组,差异有统计学意义(P<0.05);治疗后2组CD4^(+)和CD4^(+)/CD8^(+)均升高,CD8^(+)均下降,且治疗后B组CD4^(+)和CD4^(+)/CD8^(+)均高于A组,CD8^(+)低于A组,上述差异有统计学意义(P<0.05);治疗后2组总IgE水平均下降,且治疗后B组总IgE低于A组,上述差异均有统计学意义(P<0.05);2组不良反应发生率对比差异无统计学意义(P>0.05)。结论维生素D佐治特发性荨麻疹患者可减轻症状,增强疗效,还可改善T淋巴细胞亚群水平,控制总IgE水平,调节免疫。

Objective In order to observe the effects of vitamin D on patients with idiopathic urticaria,and to explore the effects on T lymphocyte subsets and humoral immune levels.Methods The data of 84 patients with idiopathic urticaria were reviewed.According to the treatment methods,41 patients were only treated by routine therapy,which was recorded as group A,and the other 43 patients were treated with vitamin D,which were recorded as group B.The symptom scores,clinical effect,changes of T lymphocyte subsets and humoral immune levels before and after treatment,adverse reactions were compared.Results After two weeks and after treatment,the symptom scores of both groups were lower than before treatment.After treatment the symptom scores of both groups were lower than after two weeks,which in group B were lower than those in group A after two weeks and after treatment,with statistically significant differences(P<0.05).There was significant differences in the effect distribution between the two groups(P<0.05).The total effective rate of group B was higher than that of group A(P<0.05).After treatment,CD4^(+)and CD4^(+)/CD8^(+)were increased and CD8^(+)were decreased in both groups.After treatment,CD4^(+)and CD4^(+)/CD8^(+)in group B were higher than those in group A,and CD8^(+)was lower than that in group A,with statistically significant differences(P<0.05).After treatment,the total IgE levels of both groups decreased,and the total IgE level of group B was lower than that of group A(P<0.05).There were no significant differences in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Vitamin D can reduce symptoms,enhance curative effect,improve T lymphocyte subsets,control total IgE level and regulate immunity in patients with idiopathic urticaria.