运动相关创伤性脑损伤的新兴三维体外模型研究进展

Recent advances in emerging three-dimensional in vitro models for sport-related traumatic brain injury

运动相关创伤性脑损伤(srTBI)是在运动过程中导致的创伤性脑损伤(TBI),可引起认知和运动功能障碍。目前,srTBI分子机制研究以及相关药物研发主要依赖单层细胞培养模型和动物模型。但是,这些模型在模拟脑部细胞种群、炎症反应等方面与人类srTBI的病理生理过程存在差异,使得基于以上模型得出的大部分研究成果难以有效地指导临床治疗。新兴三维(3D)体外模型作为医学领域的创新研究工具,弥补了传统模型在模拟人类srTBI病理生理过程的局限,为进一步理解和认知srTBI提供新的手段。虽然,已有文献报道了新兴3D体外模型在神经系统性疾病中的研究进展,但缺乏上述模型在srTBI研究中的系统性梳理和总结。本文综述了新兴3D体外模型在srTBI中的研究进展,探讨了现有模型的优势和局限,并进一步展望了srTBI模型的发展趋势。本文旨在为组织工程学及运动医学领域学者研究srTBI分子机制和研发神经保护药物提供新的研究视角。

Sports-related traumatic brain injury(srTBI)is a traumatic brain injury(TBI)caused by sports,which can result in cognitive and motor dysfunction.Currently,research on the molecular mechanism of srTBI and related drug development mainly relies on monolayer culture models and animal models.However,many differences exist in cell populations and inflammatory responses between these models and human pathophysiological processes.Most of the researches derived from the models can’t effectively conducted translational research.Emerging threedimensional(3D)in vitro models bridge the limitations of traditional models in simulating the pathophysiological processes of human srTBI and provide new means to understand srTBI.A literature has reported the research progress of emerging 3D in vitro models in neurological diseases,but there is a lack of systematic summary of the mentioned models in srTBI studies.Here,we review the research progress of emerging 3D in vitro models of srTBI,discuss the advantages and limitations of existing models,and further prospect the future trend of srTBI models.This paper aims to provide a new research perspective for researchers in tissue engineering and sports medicine to study the molecular mechanisms of srTBI and develop neuroprotective drugs.