摘要
目的分析肝癌疾病特点,评价血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)在病理诊断中的价值。方法选取50例原发性肝癌(PHC)患者作为观察1组、50例良性肝病患者作为观察2组、50例同期在本院进行健康体检者作为对照组。三组均行VEGF、MMP-9病理诊断,分析比较三组受试者的VEGF、MMP-9水平及阳性表达情况。结果观察1组与观察2组患者的VEGF、MMP-9阳性表达率均高于对照组,且观察1组VEGF、MMP-9阳性表达率分别为70.00%、66.00%,均高于观察2组的26.00%、28.00%,差异均具有统计学意义(P<0.05)。观察1组与观察2组患者的VEGF、MMP-9水平均高于对照组,且观察1组的VEGF、MMP-9水平分别为(221.10±55.50)ng/L、(141.03±45.50)ng/ml,均高于观察2组的(95.30±33.50)ng/L、(121.60±40.05)ng/ml,差异均具有统计学意义(P<0.05)。结论尽早诊断、治疗是提高肝癌疾病预后的关键,病理诊断中应用VEGF、MMP-9可以提高PHC患者疾病诊断准确率,用于疾病早期诊断与治疗具有积极意义。
Objective To analyze the characteristics of liver cancer and evaluate the value of vascular endothelial growth factor(VEGF)and matrix metalloproteinase-9(MMP-9)in pathological diagnosis.Methods There were 50 patients with primary hepatic carcinoma(PHC)selected as observation group 1,50 patients with benign liver disease as observation group 2 and 50 healthy subjects as the control group.Pathological diagnosis of VEGF and MMP-9 was performed in the three groups,and the levels and positive expression of VEGF and MMP-9 of the three groups were analyzed and compared.Results The positive expression rates of VEGF and MMP-9 in observation group 1 and observation group 2 were higher than those in the control group;the positive expression rates of VEGF and MMP-9 in observation group 1 were 70.00%and 66.00%,respectively,which were higher than 26.00%and 28.00%in observation group 2;all the difference was statistically significant(P<0.05).The levels of VEGF and MMP-9 in observation group 1 and observation group 2 were higher than those in the control group;the levels of VEGF and MMP-9 in observation group 1 were(221.10±55.50)ng/L and(141.03±45.50)ng/ml,which were higher than(95.30±33.50)ng/L and(121.60±40.05)ng/ml in observation group 2;all the differences were statistically significant(P<0.05).Conclusion Early diagnosis and treatment of liver cancer is the key to improving the prognosis.The application of VEGF and MMP-9 in pathological diagnosis can improve the accuracy of the diagnosis of PHC patients,and it is of positive significance for early diagnosis and treatment of the disease.
作者
陈宁
CHEN Ning(Department of Pathology,966 Hospital of the Joint Support Force of the Chinese People’s Liberation Army,Dandong 118000,China)
出处
《中国现代药物应用》
2021年第16期32-34,共3页
Chinese Journal of Modern Drug Application
关键词
血管内皮生长因子
基质金属蛋白酶-9
肝癌
病理诊断
阳性表达率
Vascular endothelial growth factor
Matrix metalloproteinase-9
Liver cancer
Pathological diagnosis
Positive expression rate