盐酸氨溴索治疗老年慢性阻塞性肺疾病急性加重期的疗效分析

Analysis of the efficacy of ambroxol hydrochloride in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

目的分析盐酸氨溴索治疗老年慢性阻塞性肺疾病(慢阻肺)急性加重期患者的临床效果及预后生活质量。方法48例老年慢阻肺急性加重期患者,依据治疗方法的不同分为对照组与观察组,各24例。对照组采用常规治疗方案治疗,观察组在常规治疗基础上加用盐酸氨溴索静脉滴注治疗。对比两组临床疗效、治疗后症状控制情况及慢性阻塞性肺疾病评估测试(CAT)评分。结果观察组治疗总有效率为95.83%,高于对照组的66.67%,差异有统计学意义(P<0.05)。观察组患者药物起效时间(2.92±1.17)d及疾病控制时间(6.13±1.84)d均短于对照组的(3.75±1.48)、(7.54±2.76)d,差异有统计学意义(P<0.05)。治疗后,两组患者CAT评分均低于本组治疗前,且观察组低于对照组,差异均具有统计学意义(P<0.05)。结论盐酸氨溴索静滴治疗老年慢阻肺急性加重期的效果显著,能够在缩短治疗时间的基础上,较大程度提升治疗效果,进而改善患者的生活质量和生活品质,具有较高的应用和推广价值。

Objective To analyze the clinical effect and prognosis of ambroxol hydrochloride in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease.Methods A total of 48 elderly patients with acute exacerbation of chronic obstructive pulmonary disease were divided into a control group and an observation group according to different treatment methods,with 24 cases in each group.The control group was treated with conventional therapy,and the observation group was treated with ambroxol hydrochloride intravenous drip based on conventional therapy.The clinical efficacy,symptom control and chronic obstructive pulmonary disease assessment test(CAT)scores after treatment were compared between the two groups.Results The total effective rate 95.83%of the observation group was higher than 66.67%of the control group,and the difference was statistically significant(P<0.05).The drug onset time(2.92±1.17)d and disease control time(6.13±1.84)d of the observation group were shorter than(3.75±1.48)and(7.54±2.76)d of the control group,and the difference was statistically significant(P<0.05).After treatment,the CAT scores of the two groups were lower than those of this group before treatment,and the observation group was lower than the control group.All the difference was statistically significant(P<0.05).Conclusion Ambroxol hydrochloride intravenous drip has significant effect in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease,and it can greatly improve the treatment effect while shortening the treatment time,and then improve the quality of life of patients,which has high application and promotion value.