研究双歧杆菌四联活菌片辅助治疗轻中度溃疡性结肠炎的疗效

Study on the efficacy of bifidobacterium tetravaccine tablets(live)in the adjuvant treatment of mild to moderate ulcerative colitis

目的研究在辅助治疗轻中度溃疡性结肠炎(UC)时应用双歧杆菌四联活菌片的效果。方法80例轻中度溃疡性结肠炎患者,根据电脑随机方式将其分为参照组和实验组,每组40例。参照组给予美沙拉嗪治疗,实验组给予美沙拉嗪联合双歧杆菌四联活菌片治疗。比较两组患者治疗效果以及治疗前后的Mayo评分、生活质量。结果实验组治疗总有效率为97.50%,高于参照组的77.50%,差异具有统计学意义(P<0.05)。治疗后,实验组Mayo评分(3.17±2.09)分明显低于参照组的(5.74±2.63)分,差异具有统计学意义(P<0.05)。治疗后,实验组生活质量评分(93.74±2.78)分高于参照组的(82.49±2.37)分,差异具有统计学意义(P<0.05)。结论在辅助治疗轻中度溃疡性结肠炎时,应用双歧杆菌四联活菌片能够提升治疗效果,加快患者恢复速度,值得推广和应用。

Objective To study the effect of bifidobacterium tetravaccine tablets(live)in the adjuvant treatment of mild to moderate ulcerative colitis.Methods A total of 80 patients with mild to moderate ulcerative colitis were randomly divided into a reference group and an experimental group,with 40 cases in each group.The reference group was treated with mesalazine,and the experimental group was treated with mesalazine and bifidobacterium tetravaccine tablets(live).The therapeutic effect,Mayo score and quality of life before and after treatment were compared between the two groups.Results The total effective rate in the experimental group was 97.50%,which was higher than 77.50%in the reference group,and the difference was statistically significant(P<0.05).After treatment,the Mayo score(3.17±2.09)points of the experimental group was significantly lower than(5.74±2.63)points of the reference group,and the difference was statistically significant(P<0.05).After treatment,the quality of life score(93.74±2.78)points of the experimental group was higher than(82.49±2.37)points of the reference group,and the difference was statistically significant(P<0.05).Conclusion In the adjuvant treatment of mild to moderate ulcerative colitis,the application of bifidobacterium tetravaccine tablets(live)can improve the therapeutic effect and accelerate the recovery of patients,which is worthy of promotion and application.