沙参麦冬汤加减治疗肺阴亏耗证慢阻肺的临床疗效研究

Study on the clinical efficacy of modified Shashen Maidong Decoction on chronic obstructive pulmonary disease with pulmonary Yin deficiency syndrome

目的探讨沙参麦冬汤加减治疗肺阴亏耗证慢性阻塞性肺疾病(慢阻肺)的临床疗效。方法90例肺阴亏耗证慢阻肺患者,随机分为对照组和研究组,每组45例。对照组采用常规西医治疗,研究组在对照组基础上采用沙参麦冬汤加减治疗。比较两组治疗后肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、第1秒用力呼气容积占用力肺活量的百分比(FEV1/FVC)]、主要症状体征积分、6 min步行距离和12个月内急性加重次数。结果治疗后,研究组FEV1、FVC、FEV1/FVC分别为(1.89±0.47)L、(2.88±0.73)L、(66±13)%,均高于对照组的(1.54±0.61)L、(2.40±0.58)L、(60±11)%,差异具有统计学意义(P<0.05)。研究组咳嗽积分为(1.28±0.66)分、痰量积分为(0.81±0.59)分、痰液性质积分为(0.74±0.22)分、呼吸困难积分为(1.68±0.50)分、啰音积分为(0.57±0.11)分,均明显低于对照组的(1.62±0.40)、(1.55±0.67)、(1.33±0.59)、(1.96±0.48)、(0.94±0.16)分,差异具有统计学意义(P<0.05)。研究组12个月内急性加重次数(2.15±0.49)次明显少于对照组的(3.89±0.64)次,6 min步行距离(357.11±36.94)m明显长于对照组的(309.62±46.84)m,差异具有统计学意义(P<0.05)。结论沙参麦冬汤加减治疗肺阴亏耗证慢阻肺患者可有效改善临床症状,改善肺功能,增强运动耐力,减少急性加重次数。

Objective To discuss the clinical efficacy of modified Shashen Maidong Decoction on chronic obstructive pulmonary disease with pulmonary Yin deficiency syndrome.Methods A total of 90 patients with chronic obstructive pulmonary disease due to deficiency of pulmonary Yin syndrome were randomly divided into control group and research group,with 45 cases in each group.The control group was treated with routine Western medicine,and the research group was treated with modified Shashen Maidong Decoction on the basis of the control group.The pulmonary function indicators before and after treatment,main symptom and sign scores,6-min walking distance,and number of acute aggravation within 12 months were compared between the two groups.Results After treatment,the FEV1,FVC and FEV1/FVC of the research group were(1.89±0.47)L,(2.88±0.73)L and(66±13)%,which were all higher than(1.54±0.61)L,(2.40±0.58)L and(60±11)%of the control group,and the difference was statistically significant(P<0.05).The cough score(1.28±0.66)points,sputum volume score(0.81±0.59)points,sputum property score(0.74±0.22)points,dyspnea score(1.68±0.50)points,rales score(0.57±0.11)points of the research group were obviously lower than(1.62±0.40),(1.55±0.67),(1.33±0.59),(1.96±0.48)and(0.94±0.16)points of the control group,and the difference was statistically significant(P<0.05).The number of acute aggravation within 12 months(2.15±0.49)times of the research group was obviously less than(3.89±0.64)times of the control group,and 6-min walking distance(357.11±36.94)m was obviously longer than(309.62±46.84)m of the control group.All the difference was statistically significant(P<0.05).Conclusion Modified Shashen Maidong Decoction can effectively improve the clinical symptoms,improve the pulmonary function,enhance the exercise endurance,and reduce the number of acute exacerbations in patients with chronic obstructive pulmonary disease.