胚胎期颞下颌关节发育相关信号分子与转录因子研究进展

Research progress in signal molecules and transcription factors related to the development of temporomandibular joint in embryonic stage

颞下颌关节(temporomandibular joint,TMJ)是哺乳动物特有的滑膜关节,在胚胎发育期的结构和功能已多有报道。尽管自20世纪就开展了胚胎发育期TMJ相关信号分子与转录因子的研究,然而与四肢滑膜关节丰富的分子调控信息相比,对TMJ的分子遗传控制信息还知之甚少。关于TMJ胚胎发育的信号分子与转录因子研究主要以啮齿类动物为主,大型哺乳动物与人类胚胎期TMJ发育相关调控分子以及它们的调控机制研究鲜有报道。为了在现代分子生物学技术的基础上发现更多、更核心的调控分子并了解其对TMJ发育的调控机制,本文对当前TMJ胚胎发育中的关键信号分子与转录因子的研究进展进行综述。

Temporomandibular joint(TMJ)is a unique synovial joint in mammals.There have been many reports on the structure and function of TMJ during embryonic development.Although studies on TMJ related signal molecules and transcription factors during embryonic development have been carried out since the last century,there are few reports on the molecular genetic regulation of TMJ compared with the abundant molecular regulation information of synovial joint.The studies on signal molecules and transcription factors of TMJ embryonic development were mainly conducted in rodents.There were few studies on the regulatory molecules and their regulatory mechanisms related to the development of TMJ conducted in large mammals and human embryos.This article reviews the research progress of key signal molecules and transcription factors of TMJ in embryonic development on the basis of modern molecular biology technology in order to find more core regulatory molecules and understand their regulation mechanism on TMJ development.