ICP-MS法测定原料药(沙库巴曲缬沙坦钠)中6种有害元素含量研究

Determination of six harmful elements in raw material medicine(sakubatr valsartan sodium)by ICP-MS.

目的:电感耦合等离子体质谱法具有检出限低、线性范围宽、多元素同时测定等优点,本实验研究电感耦合等离子体质谱法测定原料药(沙库巴曲缬沙坦钠)中主要含有的6种有害元素含量测试。方法:采用硝酸加高氯酸的混酸体系进行前处理消解样品,利用电感耦合等离子体质谱法对其中可能含有的6种有害元素进行了定量分析。结果:该方法的相关系数均为0.999以上。利用该检测方法,回收率指标良好,达到94.65%-100.80%之间。方法检出限在2.63-35.5(μg·g^(-1))之间,6种有害元素的精密度实验RSD指标在5%以内。结论:本实验提出的ICP-MS法快速、灵敏、准确,可以完全用于原料药(沙库巴曲缬沙坦钠)中主要含有的6种有害元素的测定。

ICP-MS method has advantages of low detection limit,wide linear range and simultaneous determination of multiple elements.The correlation coefficient of this method is more than 0.999.The recovery rate is good,ranging from 94.65%to 100.80%.The detection limit is in 2.63—35.5(μg·g^(-1)).The precision experimental RSD of the 6 elements are less than 5%.This method is rapid,sensitive and accurate,and can be used in the determination of the raw material medicine(sakubatr valsartan sodium).