肠道菌群对耐碳青霉烯类肠杆菌科细菌定殖抗性的研究进展

Research progress on the colonization resistance of intestinal flora to carbapenem-resistant Enterobacteriaceae

耐碳青霉烯类肠杆菌科细菌(carbapenem-resistant Enterobacteriaceae,CRE)在肠腔中定殖通常先于或并存于CRE的感染。正常情况下,定殖的CRE、肠道菌群和宿主相互作用,处于稳定平衡的状态,当肠道菌群出现失调时,肠道正常菌群失去对定殖CRE的抵抗力,增加CRE感染的风险。大量研究表明通过肠道共生菌群对CRE的定殖抗性不仅可以预防感染,而且也可以降低医疗环境中患者间相互传播的风险。本文就CRE的流行现状、肠杆菌科细菌定殖机制以及肠道共生菌群对CRE定殖抗性机制作一综述,以期为CRE感染的防控工作提供新思路和新方法。

The colonization of carbapenem-resistant Enterobacteriaceae(CRE)in the intestinal lumen usually precedes or coexists with CRE infection.The intestinal flora and host normally interact with the colonized CRE to achieve a stable equilibrium state.When dysbacteriosis happens,the intestinal flora losses its resistance to the colonized CRE,increasing the risk of CRE infection.A large number of studies suggest that the resistance of intestinal symbiotic flora to the colonization of CRE can not only prevent infection,but also reduce the risk of mutual transmission among patients exposed to the medical environment.To provide a new idea and method for prevention and control of CRE infection,we studied the prevalence of CRE,the colonization mechanisms of Enterobacteriaceae,and the mechanisms of colonizing resistance to CRE of intestinal flora.