分子碘催化多组分反应合成取代咪唑类衍生物

Iodine Promoted Multi-Component Synthesis of Substituted Imidazoles

以苯甲醛、安息香、醋酸铵为多组分起始底物,一锅法合成了多取代咪唑类衍生物。该反应仅以分子碘为催化剂就可以在二甲基亚砜(DMSO)溶剂中发生。此外,在反应中通过加入底物6-胺基己酸或更换为苯胺,合成了不同的四取代咪唑以及长烷基链羧酸咪唑化合物。该反应为药物开发和新颖有机材料的发展提供了一种新方法。

Substituted imidazoles were synthesized through a one-pot reaction by using benzaldehyde,benzoin and ammonium acetate as starting materials.This reaction can occur in Dimethyl sulfoxide(DMSO)only with molecular iodine as catalyst.In addition,by adding 6-aminohexanoic acid or substituting aniline,different tetrasubstituted imidazoles and imidazoles with long alkyl chain carboxylic acids can be synthesized.This reaction provides a new method for drug development and rapid development of new organic materials.