摘要
为确证1批恩诺沙星注射液中的非法添加物,通过HPLC-PDA法初筛,利用高分辨质谱对未知物进行筛查,并用HPLC-PDA和UPLC-Triple TOF MS两种方法进行验证,结果显示,该批样品中的非法添加物为加替沙星。本研究为兽药中非法添加物筛查及定性确证提供了一个有效的思路与方法。
To confirm the illegal addition in one batch of enrofloxacin injection.The unknown substance was screened by HPLC-PDA high-resolution mass spectrometry,and confirmed by combined HPLC-PDA and UPLC-Triple TOF MS,The results showed that the illegal additive in this batch of enrofloxacin injection was gatifloxacin.This study provides an effective ideas and method for the illegal additives qualitative analysis in veterinary drugs.
作者
宋慧敏
熊玥
汪云花
孙瑶
石慧慧
SONG Hui-min;XIONG Yue;WANG Yun-hua;SUN Yao;SHI Hui-hui(Jiangsu Testing Institute of Veterinary Drug and Feed,Nanjing 210036,China)
出处
《中国兽药杂志》
2021年第8期54-59,共6页
Chinese Journal of Veterinary Drug
关键词
恩诺沙星注射液
非法添加
加替沙星
确证
enrofloxacin injection
illegal addition
gatifloxacin
identification
