血清中氧化甾醇水平在孤独症谱系障碍儿童早期识别中的价值

Value of serum oxidized sterol level in early identification of children with autism spectrum disorders

目的探讨血清氧化甾醇水平在孤独症谱系障碍患儿早期识别中的价值。方法于2018年5-9月收集本院收治的孤独症谱系障碍患儿55例作为观察组,收集同期至本院体检的健康儿童55例作为对照组。比较两组血脂、血清葡萄糖、超敏C反应蛋白、氧化甾醇水平,采用受试者工作特征(ROC)曲线分析血清氧化甾醇水平对孤独症谱系障碍的诊断效能。结果两组总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白、血清葡萄糖、超敏C反应蛋白水平比较,差异均无统计学意义(P>0.05);与对照组比较,观察组血清24-羟基胆固醇水平升高[(113.91±25.20)ng/mL vs.(94.76±16.98)ng/mL,P<0.001];7α-羟基胆固醇水平降低[(41.16±6.75)ng/mL vs.(45.96±6.96)ng/mL,P<0.001];25-羟基胆固醇水平降低[(6.45±2.93)ng/mL vs.(8.08±3.01)ng/mL,P=0.005]。两组血清27-羟基胆固醇水平比较,差异无统计学意义(P=0.342)。24-羟基胆固醇诊断孤独症谱系障碍的ROC曲线下面积为0.688[95%CI(0.588,0.787),P=0.001],高于7α-羟基胆固醇和25-羟基胆固醇。结论24-羟基胆固醇在诊断孤独症谱系障碍患儿中具有较好的诊断价值。

Objective To explore the value of serum oxysterol levels in early identification of autism spectrum disorders in children.Methods Fifty-five children with autism spectrum disorder treated in this hospital from May to September 2018 were collected as the observation group,and contemporaneous 55 healthy children undergoing physical examination were served as the control group.The levels of blood lipid,serum glucose,hypersensitivity C reactive protein and oxysterol were compared between the two groups.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficiency of serum oxysterol level in children with autism spectrum disorder.Results There was no statistically significant difference in levels of total cholesterol,triglyceride,high-density lipoprotein,low-density lipoprotein,serum glucose and high-sensitivity C-reactive protein between the two groups(P>0.05).Compared with the control group,the serum 24-hydroxycholesterol level in the observation group was increased[(113.91±25.20)ng/mL vs.(94.76±16.98)ng/mL,P<0.001],the 7-alpha-hydroxycholesterol level was decreased[(41.16±6.75)ng/mL vs.(45.96±6.96)ng/mL,P<0.001],the 25-hydroxycholesterol level was decreased[(6.45±2.93)ng/mL vs.(8.08±3.01)ng/mL,P=0.005].There was no statistically significant difference in the 27-hydroxycholesterol level between the two groups(P=0.342).The area under the ROC curve of 24-hydroxycholesterol in diagnosing autism spectrum disorders was 0.688[95%CI(0.588,0.787),P=0.001],which was higher than that of 7-hydroxycholesterol and 25-hydroxycholesterol.Conclusion 24-hydroxycholesterol has a good diagnostic value in the diagnosis of children patients with autism spectrum disorder.