Caspase-1及其在心血管疾病中的作用研究进展

Research progress of caspase-1 and its role in cardiovascular diseases

细胞焦亡作为一种新发现的细胞程序性死亡方式,可由天冬氨酸特异性半胱氨酸蛋白酶-1(caspase-1)介导。越来越多的研究表明,在心血管疾病(CVD)的病理过程中,caspase-1介导的细胞焦亡参与动脉粥样硬化、缺血/再灌注损伤、心力衰竭、肺动脉高压等多种CVD的发生与发展。本文就caspase-1的结构与功能、其与细胞焦亡的关系,以及其在CVD中的研究进展作一综述。

Pyroptosis is a newly discovered way of programmed cell death,which can be mediated by caspase-1.More and more studies have shown that in the pathological process of cardiovascular diseases(CVD),pyroptosis mediated by caspase-1 is involved in the occurrence and development of atherosclerosis,ischemia/reperfusion injury,heart failure,pulmonary hypertension,and other CVDs.This article reviewed the structure and function of caspase-1,its relationship with pyroptosis,and its research progress in CVD.