祛痰化瘀法治疗高脂血症相关性血管性痴呆临床观察

Clinical Observation on Treatment in Patients with Hyperlipidemia Vascular Dementia by Eliminating Phlegm and Re⁃moving Blood Stasis

目的:观察自拟开窍醒脑汤对高脂血症相关性血管性痴呆(VaD)的疗效。方法:选取黑龙江省医院中西医结合科及神经内科VaD合并血脂异常患者56例,采用随机分组法将其分为治疗组和对照组,每组各28例。治疗组给予自拟开窍醒脑汤,对照组给予奥拉西坦胶囊联合阿托伐他汀钙片。对两组患者疗效进行评价,并分别比较两组患者治疗前后认知水平、血清脂质变化水平等。结果:治疗组总有效率为85.71%,对照组总有效率为57.14%。治疗组、对照组治疗后MMSE、HDS评分均高于治疗前,差异有统计学意义(治疗组t值分别为6.58、4.68,对照组t分别为3.39、2.84,P值均<0.05)。治疗组与对照组治疗后血清脂质水平均有改善,两组治疗后TG、LDL的含量显著降低,HDL明显升高,差异有统计学意义(治疗组t值分别为-5.51、3.51和-4.50,对照组t值分别为-2.85、2.55和2.40,P值均<0.05)。结论:自拟开窍醒脑汤治疗高脂血症相关性血管性痴呆疗效确切,可以改善患者认知水平,且能同时降低患者血清脂质水平。

OBJECTIVE To observe the therapeutic effect of Kaiqiao Xingnao Decoction on hyperlipidemia vascular dementia and hyperlipidemia.METHODS 56 patients diagnosed with vascular dementia combined with hyperlipidemia admitted to department of integrated chinese and western medicine and neurology department in Heilongjiang provincial hospital were randomly divided into treatment group and control group,28 cases in each group.Patients in treatment group were treated by Kaiqiao Xingnao Decoction,and the patients in control group were given by Oxiracetam capsule and Atorvastatin calcium at the same time.Evaluating the cura⁃tive effect of the two groups,including the cognitive level,blood lipid level before and after the treatment.RESULTS After the treat⁃ment,the total effective rate of treatment group was 85.71%,and the other one was 57.14%.Both the MMSE score and HDS score of two groups after treatment were higher than before.The level of lipid index highly improved after the treatment in two groups.TG and LDL of treatment group were highly decreased than before with HDL increased obviously(P<0.05).CONCLUSION Kaiqiao Xingnao Decoction was effective in the treatment of vascular dementia combined with hyperlipidemia,which could improve the cogni⁃tive level of patients and decrease the level of lipid index.