癌性恶病质发病机制的研究进展

Research progress on pathogenesis of cancer cachexia

癌性恶病质是一类复杂的代谢综合征,包括肌肉消耗、脂肪消耗、非计划的体质量下降、厌食和免疫功能破坏等。恶病质可显著降低肿瘤患者的抗肿瘤治疗疗效,增加治疗毒副反应,加重患者的症状,影响患者的生活质量,并最终缩短患者的生存时间。深入理解癌性恶病质的发病机制对于指导合理的治疗具有重要意义。该文将对癌性恶病质的发病机制进行综述,主要包括肿瘤坏死因子α、白细胞介素1和6、信号转导及转录激活蛋白3等炎症因子介导的机体炎症反应以及机体营养代谢异常和线粒体功能异常。

Cancer cachexia is a complex metabolic syndrome characterized by muscle wasting,fat decomposition,unplanned weight loss,anorexia and immune dysfunction.Cachexia can significantly reduce the efficacy of antitumor therapies and increase treatment-related toxicity on cancer patients.It increases the symptom burden in patients,affects the quality of their life,ultimately shortens patients'survival.Lucubrating the pathogenesis of cachexia is of great significance to provide rationale treatment guidance.Here we reviewed the research progress on pathogenesis of cancer cachexia,including inflammatory response mediated by TNF-α,IL-1,IL-6 and STAT-3 and abnormal nutrition metabolism,as well as mitochondrial dysfunction.