摘要
Background:Tuberculosis/HIV co-infection is a bidirectional and synergistic combination of two very important pathogens in public health.To date,there have been limited clinical data regarding mortality rates among tuberculosis/HIV co-infected patients and the impact of antiretroviral therapy on clinical outcomes in Ethiopia.This study assessed the incidence and predictors of tuberculosis/HIV co-infection mortality in Southwest Ethiopia.Methods:A retrospective cohort study collated tuberculosis/HIV data from Jimma University Teaching Hospital for the period of September 2010 and August 2012.The data analysis used proportional hazards cox regression model at P value of≤0.05 in the final model.Results:Fifty-five(20.2%)patients died during the study period and 272 study participants contributed 3082.7 person month observations.Factors including:being aged between 35–44 years(AHR=2.9;95%CI:1.08–7.6),being a female sex worker(AHR=9.1;95%CI:2.7–30.7),being bed ridden as functional status(AHR=3.2;95%CI:1.2–8.7),and being at World Health Organization HIV disease stages 2(AHR=0.2;95%CI:0.06–0.5),3(AHR=0.3;95%CI:0.1–0.8)and 4(AHR=0.2;95%CI:0.04–0.55)were significant predictors of mortality for tuberculosis/HIV co-infected patients.Conclusions:Contrary to our expectations,the World Health Organization(WHO)HIV disease stage 1 was found to be a significant predictor of mortality.Higher mortality rates were observed in WHO disease stage 1 patients compared to patients in stages 2,3 and 4.The current study also confirmed and reaffirmed known significant predictors of the mortality for tuberculosis/HIV co-infected patients including being 35–44 years,being a female sex worker and being bed ridden functional status.The occurrence of high death rate among tuberculosis/HIV co-infected cases needs actions to reduce this poor outcome.
基金
funded by Jimma University and was received by Hailay Gesesw.The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript.
