舒血宁注射液治疗急性脑梗死临床研究

Clinical Study on Shuxuening Injection for Acute Cerebral Infarction

目的:观察舒血宁注射液治疗脑梗死的临床疗效。方法:将90例急性脑梗死患者依据床号末位单双号方式分为对照组和观察组各45例。2组均给予控制血压、血糖及颅内脱水等常规治疗,对照组加用双联抗血小板药物治疗,观察组加用舒血宁注射液静脉注射治疗。2组均持续治疗2周,观察比较2组临床疗效、治疗前后血清炎性因子水平以及左、右侧脑血流动力学指标。结果:观察组总有效率为95.56%,对照组为86.67%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组血清C-反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)比较,差异无统计学意义(P>0.05);治疗后,2组CRP、IL-6、IL-8水平均较治疗前降低(P<0.05),且观察组各项指标均低于对照组(P<0.05)。治疗前,2组左、右侧脑血流最大速度、平均速度、脑血流灌注指数比较,差异无统计学意义(P>0.05);治疗后,2组左、右侧脑血流最大速度、平均速度均较治疗前升高(P<0.05),血流灌注指数较治疗前降低(P<0.05),且观察组上述指标改善较对照组更显著(P<0.05)。结论:舒血宁注射液治疗急性脑梗死可有效改善患者神经功能,降低炎症反应,促进脑部血液循环,从而提高临床疗效。

Objective:To observe the clinical effect of Shuxuening injection for acute cerebral infarction.Methods:A total of 90 cases of patients with Shuxuening injection were divided into the control group and the observation group by the oddeven number grouping method according to their tail number of bed number,45 cases in each group.Both groups were given routine treatment including control of blood pressure and blood glucose as well as intracranial dehydration;the control group was additionally treated with dual antiplatelet drugs,and the observation group was additionally given intravenous injection with Shuxuening injection.Both groups were treated for two weeks.The levels of inflammatory factors in serum and the cerebral hemodynamic indexes in both sides before and after treatment as well as the clinical effect in the two groups were observed and compared.Results:The total effective rate was 95.56% in the observation group and 86.67% in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of C-reactive protein(CRP),interleukin-6(IL-6)and interleukin-8(IL-8)in serum between the two groups(P>0.05).After treatment,the levels of CRP,IL-6 and IL-8 in the two groups were decreased when compared with those before treatment(P<0.05),and the indexes in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of maximum velocity,mean velocity and perfusion indexes of cerebral blood flow in both sides between the two groups(P>0.05).After treatment,the maximum velocity and mean velocity of cerebral blood flow in both sides in the two groups were increased when compared with those before treatment(P<0.05),and the blood perfusion indexes were decreased(P<0.05);the improvement of the above indexes in the observation group was more significant than that in the control group(P<0.05).Conclusion:Shuxuening injection for acute cerebral infarction can effectively improve neurological function of patients,reduce inflammatory reactions,promote blood circulation in the brain,so as to improve the clinical effect.