ABCC9基因与神经精神疾病相关性的研究进展

Correlation between ABCC9 gene and neuropsychiatric diseases

多种神经精神疾病与钾离子通道改变相关。三磷酸腺苷结合盒C亚家族9成员(ABCC9)基因编码的磺酰脲2受体(SUR2)是三磷酸腺苷敏感的钾离子通道(KATP)通道的重要组分,调节KATP通道的活性,参与KATP通道将细胞代谢状态与膜兴奋性耦合,从而调节神经细胞兴奋性、神经发育、神经递质的释放、神经保护,影响神经精神疾病的发生和发展过程。

A variety of neuropsychiatric diseases are associated with potassium channels.The sulfonylurea receptor 2(SUR2)encoded by ATP-binding cassette,sub-family C member 9(ABCC9)gene is an important component of ATP-sensitive potassium channel(KATP).As the regulatory component,SUR2 participates in KATP channel to couple the cell metabolic state and membrane excitability,thereby regulating nerve cell excitability,neurodevelopment,neurotransmitter release,and nerve protection,affecting the occurrence and development of neuropsychiatric diseases.