SCC⁃Ag、CEA、EB病毒VCA⁃Ig A诊断鼻窦癌价值及与化疗反应性关系

The diagnostic value of SCC⁃Ag,CEA,Epstein⁃Barr VCA⁃Ig A in the diagnosis of sinus cancer and its relationship with chemotherapy response

目的探讨鳞状上皮细胞癌抗原(SCC⁃Ag)、癌胚抗原(CEA)、EB病毒壳抗原免疫球蛋白A抗体(EBVCA⁃IgA)诊断鼻窦癌价值及与化疗反应性关系。方法选取本院120例鼻窦癌患者(鼻窦癌组)及同期45例鼻窦炎患者(鼻窦炎组)、45例健康人群(对照组),比较3组一般资料、SCC⁃Ag、CEA、EBVCA⁃IgA水平,分析鼻窦癌影响因素,评价SCC⁃Ag、CEA、EBVCA⁃IgA对鼻窦癌的诊断价值及与化疗反应性关系。结果3组SCC⁃Ag、CEA、EBVCA⁃IgA比较:鼻窦癌组>鼻窦炎组>对照组,差异有统计学意义(P<0.05)。SCC⁃Ag、CEA、EBVCA⁃IgA是鼻窦癌发生的重要因素(P<0.05)。SCC⁃Ag、CEA、EBVCA⁃IgA联合诊断鼻窦癌的AUC大于上述指标单一诊断(P<0.05)。SCC⁃Ag、CEA、EBVCA⁃IgA与鼻窦癌患者化疗反应性呈负相关(P<0.05)。结论SCC⁃Ag、CEA、EBVCA⁃IgA共同检测上述指标可作为鼻窦癌诊断与化疗反应性观察的重要手段。

Objective To investigate the diagnostic value of squamous cell carcinoma antigen(SCC⁃Ag),carcinoembryonic antigen(CEA),and Epstein⁃Barr viral capsid antigen immunoglobulin A(EBV⁃CA⁃IgA)in the diagnosis of sinus cancer and the relationship with chemotherapy response.Methods A total of 120 patients with sinus cancer(sinus cancer group),45 patients with sinusitis(sinusitis group)and 45 healthy people(control group)during the same period were selected.The general information,SCC⁃Ag,CEA,and EVCCA⁃IgA levels of the 3 groups were compared.The influencing factors of sinus cancer were analyzed,and The diagnostic value of SCC⁃Ag,CEA,EBVCA⁃IgA for sinus cancer and the relationship with chemothera⁃py response were evaluated.Results Comparison of SCC⁃Ag,CEA,EBVCA⁃IgA among the three groups:the sinus cancer group>the sinusitis group>the control group(P<0.05).SCC⁃Ag,CEA,EBBCA⁃IgA are impor⁃tant factors in the occurrence of sinus cancer(P<0.05).SCC⁃Ag,CEA,EBBCA⁃IgA combined diagnosis of si⁃nus cancer AUC is greater than that of the single diagnosis of the above indicators.SCC⁃Ag,CEA,EBBCA⁃IgA were negatively correlated with the chemotherapy response of patients with sinus cancer(P<0.05).Conclu⁃sion SCC⁃Ag,CEA,EBVCA⁃IgA combined detection can be used as an important means for the diagnosis of sinus cancer and the observation of chemotherapy response.