多囊卵巢综合征患者HOMA⁃IR与T及SHBG水平的相关性研究

Correlations of HOMA⁃IR,T and SHBG levels in patients with polycystic ovary syndrome

目的分析多囊卵巢综合征患者胰岛素抵抗指数(HOMA⁃IR)与睾酮(T)及性激素结合球蛋白(SHBG)水平的相关性。方法选取2018年1月至2019年12月本院诊治的106例多囊卵巢综合征患者作为研究组,根据HOMA⁃IR分为A组(1.66≤HOMA⁃IR<2.69)、B组(HOMA⁃IR≥2.69),另选取96例同期于本院接受健康体检且结果正常的女性作为对照组。比较各组临床特征及T、SHBG水平,采用Pearson直线分析HOMA⁃IR值分组中多囊卵巢综合征患者T与SHBG水平的相关性。结果研究组HOMA⁃IR、T水平均高于对照组,SHBG水平低于对照组,差异均有统计学意义(P<0.05)。B组体重指数(BMI)、腰臀比和多毛、痤疮发生率均高于A组,差异均有统计学意义(P<0.05)。B组T水平高于A组,SHBG水平低于A组,差异均有统计学意义(P<0.05)。Pearson直线分析结果显示:HOMA⁃IR与T呈正相关(P<0.05),与SHBG呈负相关(P<0.05)。结论HOMA⁃IR、T及SHBG水平是多囊卵巢综合征患者需要密切关注的重要指标,在多囊卵巢综合征及其代谢异常的诊断和治疗中具有临床使用价值。

Objective To analyze the correlations of HOMA⁃IR,the T and SHBG levels of pa⁃tients with polycystic ovary syndrome.Methods The 106 patients with polycystic ovary syndrome admitted to this hospital from January 2018 to December 2019 were selected as the study group,and they were divided into group A(1.66≤HOMA⁃IR<2.69)and group B(HOMA⁃IR≥2.69)according to HOMA⁃IR.In addi⁃tion,96 women who had health checkups and normal results in this hospital during the same period were se⁃lected as the control group.The clinical characteristics and T and SHBG levels between different groups were compared,and the Pearson line was used to analyze the correlation between the T and SHBG levels of patients grouped by the HOMA⁃IR value.Results The HOMA⁃IR and T levels of the study group were higher than those of the control group,and the SHBG level was lower than that of the control group,and the differences were statistically significant(P<0.05).The incidence of body mass index(BMI),waist⁃to⁃hip ratio,hirsut⁃ism and acne in group B were higher than those in group A,and the differences were statistically significant(P<0.05).The level of T in group B was higher than that in group A,and the level of SHBG was lower than that in group A,and the differences were statistically significant(P<0.05).Pearson linear analysis showed that HOMA⁃IR was positively correlated with T(P<0.05),and negatively correlated with SHBG(P<0.05).Conclusion HOMA⁃IR,T and SHBG levels are important biomarkers that need to pay close attention to the treatment of patients with polycystic ovary syndrome.The combined detection of the three has clinical value in the diagnosis and treatment of polycystic ovary syndrome and its metabolic abnormalities.