液态活检在胰腺癌早期诊断中的作用

The role of liquid biopsy in early diagnosis of pancreatic cancer

胰腺癌是一种临床发现晚、恶性程度高和预后较差的消化系统恶性肿瘤.为了改善病人的预后,探索经济、准确、微创的方法进行早期诊断,以提高手术的可切除率,具有重要的临床意义.液态活检是在可提取的体液标本中检测多种肿瘤相关生物标志物,如循环肿瘤细胞、循环肿瘤DNA和外泌体等.近年来的研究显示,液态活检在胰腺癌早期诊断中发挥着重要的作用.本文就液态活检相关标志物在胰腺癌早期诊断中的优势、局限性以及临床应用前景等方面进行综述.

Pancreatic cancer is a kind of digestive system malignant tumor with late clinical discovery,high degree of malignancy and poor prognosis.In order to improve the prognosis of patients,it is of great clinical significance to explore an economical,accurate and minimally invasive method for early diagnosis and improve the resection rate of surgery.Liquid biopsies are used to detect a variety of tumor-related biomarkers,such as circulating tumor cells,circulating tumor DNA,and exosomes,in extractable body fluid samples.Recent studies have shown that liquid biopsy plays an important role in early diagnosis of pancreatic cancer.In this paper,the advantages,limitations and clinical application prospects of liquid biopsy-related markers in early diagnosis of pancreatic cancer were reviewed.