基于核磁共振成像的健康成人排尿控制相关的脑功能网络研究

Study on brain functional networks related to micturition control in healthy adults based on magnetic resonance imaging

目的:研究健康成人因强烈排尿感而引起的与排尿控制相关的脑功能网络的改变。方法:选择年龄2550岁健康受试者43例(男20例,女23例),均为右利手。分别在膀胱空虚和强烈排尿感状态进行两次静息态功能性核磁共振成像(rs-fMRI)扫描。使用自动解剖标记(AAL)图谱将大脑皮层和皮层下结构分割为90个脑区,并计算90个脑区之间的Pearson相关系数,即功能连接(FC),构建2种状态下的脑功能网络,使用配对样本t检验(P<0.05,FDR校正后)来检测2种状态下脑区间FC差异的显著性。结果:与膀胱空虚状态相比,强烈排尿感状态默认网络(DMN)内的FC显著增强(P<0.05,FDR校正后)。结论:健康成人的排尿控制过程不是由某一大脑区域单独完成的,而是一个主要由DMN参与的过程,这可以作为膀胱功能障碍潜在的病理过程的基线,有利于促进大脑靶向疗法的出现。

Objective:To study the changes of brain functional networks related to the control of micturition in healthy adults due to the strong desire to void.Methods:Forty-three healthy subjects aged 25 to 50(20 males and 23 females)were screened,and all of them were right-handed.Two rest state-functional magnetic resonance imaging scans were performed under an empty bladder and a strong desire to void states.The cerebral cortex and subcortical structures were divided into 90 brain regions using automated anatomical labeling atlas,and the Pearson’s correlation coefficient among the 90 brain regions,namely functional connectivity(FC),was calculated to construct the brain functional network in the two states.A paired t test[P<0.05,after false discovery rate(FDR)correction]was used to detect the significance of FC difference between the two states.Results:Compared with the empty bladder state,the FC within the default mode network(DMN)of strong desire to void state significantly increased.Conclusion:We suggest that control of micturition in healthy adults should not be performed by an individual brain region,but by a complex process dominated by DMN,which can serve as a baseline for underlying the pathologic processes of bladder dysfunction and facilitate the emergence of brain-targeted therapies.