POEMS综合征三例报道并文献复习

POEMS Syndrome:Three Cases Report and Literatures Review

POEMS综合征是一种罕见的与浆细胞异常有关的副肿瘤综合征,累及多个系统,起病隐匿,临床表现复杂多样,临床上误诊率及漏诊率均较高。目前POEMS综合征的发病机制尚未完全阐明,且无统一的治疗方案。本文回顾性分析2017—2021年陕西省人民医院收治的3例POEMS综合征患者的发病机制、临床表现、辅助检查、诊断、治疗,并结合既往文献探讨该病的诊疗特点,以加强临床医师对该病的认识,提高诊断率。

POEMS syndrome is a rare paraneoplastic syndrome related to plasma cell abnormalities,involving multiple systems,insidious onset,and accompanied by complex and diverse clinical manifestations,and has higher misdiagnosis rate and missed diagnosis rate in clinic.At present,the pathogenesis of POEMS syndrome has not been fully elucidated,and there is no unified treatment plan of the disease.This article retrospectively analyzes the pathogenesis,clinical manifestations,auxiliary examinations,diagnosis,and treatment of 3 patients with POEMS syndrome admitted to Shaanxi Provincial People's Hospital from 2017 to 2021,and discuss the diagnosis and treatment characteristics of the disease combined with literatures review,in order to strengthen clinicians'understanding of the disease,and improve the diagnosis rate.