PLA2R1基因位点rs3749117和rs3749119单核苷酸多态性与特发性膜性肾病的易感性的Meta分析

Association of two polymorphisms rs3749117 and rs3749119 in PLA2R1 with idiopathic membranous nephropathy:A Meta-analysis

目的本文旨在评价两种单核苷酸多态与特发膜性肾病(idiopathic membranous nephropathy,IMN)的易感性之间的关系。方法通过系统检索PubMed、Embase等英文数据库以及中国知网、万方数据库、中国生物医学数据库(CBM)等中文数据库中关于rs3749117和rs3749119分别与IMN易感性的所有相关中英文文章。检索时限为建库至2020年10月。以OR和95%CI作为效应量,通过仔细严格的文献初筛和复筛,选择与本文主题相关的文献,以纽卡斯尔-渥太华量表(the Newcastle-Ottawa scale,NOS量表)为准进行文献评价,然后提取资料和数据,并通过stata软件进行数据处理,进行系统评价。结果本文总共纳入了7篇病例对照研究,其中有6组原始数据描述了SNP rs3749117与IMN的易感性之间的相关性,病例组1750例,对照组1593例,通过分析5种遗传模型发现,rs3749117与亚洲人IMN的易感性存在一定的相关性,基于当前纳入的研究,可以认为致病基因为T[C/T:OR=0.528,95%CI(0.372-0.749),P<0.001]。其次,6组原始数据描述了SNP rs3749119与IMN的易感性之间的相关性,并且rs3749119与亚洲人IMN易感性之间也存在明显的相关性,基于当前的研究,可以认为基因C为致病基因[C/T,OR=2.019(1.405-2.903),P<0.001]。结论PLA2R1基因位点rs3749119与rs3749117与亚洲人IMN易感性之间存现明显相关性,其中rs3749119的致病基因为C,rs3749117的致病基因为T。

Objective To evaluate the relationship between two types of single nucleotide polymorphism(SNP)and idiopathic membranous nephropathy(IMN).Methods A systematic search was performed in English databases of PubMed and Embase and Chinese databases of CNKI,WanFang and China Biology Medicine(CBM)on the susceptibility of rs3749117 and rs3749119 to IMN respectively.Odds ratio(OR)and 95%confidence interval(95%CI)were selected as the effect sizes.Through careful and rigorous preliminary screening and re-screening of the literature,the matching literatures were retrieved and Newcastle-Ottawa scale was utilized for literature evaluations.Then the relevant data were extracted and processed for Meta-analysis.Results Finally a total of 7 case-control studies were included.Six sets of original data examined the correlation between SNP rs3749117 and IMN susceptibility,including 1750 cases in case group and 1593 cases in control group.Through the analysis of 5 genetic models,rs3749117 was correlated with the susceptibility of Asian IMN.Based upon the eligible studies,the pathogenic gene was T[C/T:OR=0.528,95%CI(0.372-0.749),P<0.001].The relationship existed between SNP rs3749119 and IMN susceptibility.Meta-analysis indicated that a significant correlation existed between rs3749119 and Asian IMN susceptibility.Also based upon current researches,gene C might be a pathogenic gene[C/T,OR=2.019(1.405-2.903),P<0.001].Conclusion A distinct correlation exists between rs3749119/rs3749117 and Asian IMN susceptibility.And the pathogenic genes of rs3749119 and rs3749117 are C and T respectively.