老年患者中医体质对顺式阿曲库铵药效学的影响

The effect of traditional Chinese medicine constitution on the phar­macodynamics of cisatracurium in elderly patients

目的:探讨老年患者的中医体质分型对顺式阿曲库铵药效学的影响。方法:选择平和质(A组)、气虚质(B组)和阳虚质(C组)老年患者各15例,全麻下以TOF-WATCH SX肌松监测仪监测顺式阿曲库铵0.1mg/kg的药效学。结果:C组静注顺式阿曲库铵前的平均动脉压显著低于其余两组(P<0.001)。顺式阿曲库铵在C组起效时间较A组(P=0.009)及B组(P=0.002)延长。结论阳虚质老年患者的顺式阿曲库铵起效时间较平和质和气虚质老年患者延长。

Objective:To investigate the effect of traditional Chinese medicine(TCM)constitution on the pharmacodynamics of cisatracurium in elderly patients.Methods:elderly patients with constitutions of Ping He(group A),Qi Xu(group B)and Yang Xu(group C)were enrolled,15 patients per group.The TOF-WATCH SX monitor was used to monitor the the pharmacodynamics of cisatracurium 0.1 mg/kg.Results:The mean arterial pressure before administration of cisatracurium in group C was significantly lower than the other two groups(P<0.001).The onset time of cisatracurium in the group C was longer than that in the group A(P=0.009)and the group B(P=0.002).Conclusion:The onset time of cisatracurium in elderly patients with Yang Xu constitution is longer than that in elderly patients with Ping He and Qi Xu constitution.