GnRH-a预防子宫肌瘤挖除术后多发肌瘤复发的效果

Effect of GnRH-a on Preventing Recurrence of Multiple Myomas After Myomectomy

目的探讨腹腔镜子宫肌瘤挖除术后应用GnRH-a预防子宫多发肌瘤复发的效果。方法选取2017年3月—2018年5月在我院妇科治疗的子宫肌瘤患者60例,按照随机数字表法分为两组,对照组30例,常规腹腔镜治疗,试验组30例,在对照组基础上联用促性腺激素释放激素激动药(GnRH-a)治疗,术后18个月随访观察复发情况,比较两组患者的临床疗效、激素水平、复发率。结果试验组的临床有效率为96.67%显著高于对照组80.00%,差异具有统计学意义(P<0.05)。试验组的LH、FSH、E2等水平显著低于对照组,试验组术后18个月复发率显著低于对照组。差异具有统计学意义(P<0.05)。结论腹腔镜子宫肌瘤挖除术后应用促性腺激素释放激素激动药(GnRH-a)临床效果显著,能降低患者激素水平,有效降低子宫多发肌瘤复发率。

Objective To investigate the effect of GnRH-a on preventing recurrence of multiple uterine leiomyomas after laparoscopic myomectomy.Methods 60 patients with uterine fibroids treated in our hospital from March 2017 to May 2018 were selected and divided into two groups according to the random number table method.The control group had 30 cases,the conventional laparoscopic treatment,and the experimental group had 30 cases,the patients were treated with gonadotropin releasing hormone agonist(GnRH-a)on the basis of the control group.The recurrence was observed after 18 months of follow-up,and the clinical efficacy of the two groups was compared,hormone level,recurrence rate.Results The clinical effective rate of the experimental group was 96.67%,which was significantly higher than that of the control group was 80.00%,the difference was statistically significant(P<0.05).The levels of LH,FSH and E2 in the experimental group were significantly lower than those in the control group,and the recurrence rate in the experimental group was significantly lower than that in the control group at 18 months after surgery.The difference was statistically significant(P<0.05).Conclusion The application of gonadotropin-releasing hormone agonist(GnRH-a)after laparoscopic myomectomy has a significant clinical effect,which can reduce the hormone level of patients and effectively reduce the recurrence rate of multiple uterine myomas.