长期小剂量阿奇霉素治疗支气管扩张症的疗效观察

Observation of Clinical Effect of Long-term Low Dose Azithromycin in Treatment of Bronchiectasis

目的分析长期小剂量阿奇霉素治疗支气管扩张症的疗效。方法回顾分析我院2018年12月—2020年2月期间收治的支气管扩张症患者120例,按治疗方式分组,其中60例接受常规治疗(对照组),另60例接受常规治疗+长期小剂量阿奇霉素治疗(研究组),比较治疗效果,如疗效、管壁厚度、扩张程度、呼吸困难评分、日痰量等。结果研究组治疗疗效90.00%高于对照组73.33%,差异有统计学意义(P<0.05);治疗前组间症状指标差异无统计学意义(P>0.05),治疗后,研究组管壁厚度、扩张程度、呼吸困难评分、日痰量低于对照组,差异有统计学意义(P<0.05)。结论支气管扩张症患者接受长期小剂量阿奇霉素治疗,其症状改善更明显,疗效理想。

Objective To analyze the clinical effect of longterm low dose azithromycin in treatment of bronchiectasis.Methods 120 cases of patients with bronchiectasis and who treated in our hospital from December 2018 to February 2020 were analyzed retrospectively,and the patients were divided into two groups according to the treatment methods,60 cases received routine treatment(control group),and other 60 cases received routine treatment combined with long-term low-dose azithromycin treatment(study group).Then,the treatment effects were compared,such as the clinical effect and wall thickness,dilation degree,dyspnea score,daily sputum volume,etc.Results The treatment clinical effect in the study group was 90.00%,which was higher than that in the control group of 73.33%,and the difference was statistically significant(P<0.05);before treatment,there was little difference in symptom indexes between groups,and the difference was not statistically significant(P>0.05).After treatment,the thickness of the tube wall,the degree of dilatation,the score of dyspnea and the amount of daily sputum in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion The long-term and low-dose azithromycin in treatment of bronchiectasis which the symptom improvement are more obvious,and the clinical effects are ideal.