改善终末期肾病患者心力衰竭的新疗法

Therapies for patients with heart failure and end-stage renal disease

慢性肾脏病(chronic renal disease,CKD)和心力衰竭(heart failure,HF)的患者都在增加,以致心肾共病面临着更高的再住院率、致残率和死亡率。目前很多针对HF的临床试验皆排除终末期肾病(end-stage renal disease,ESRD)患者。极少部分研究涉及ESRD患者,本文重点阐述在HF治疗的相关研究中,有关ESRD患者的研究结果以及应用于临床的可行性。

The number of patients with chronic renal disease(CKD)and heart failure(HF)is increasing,leading to higher rates of hospitalization,disability and mortality in these patients.Most clinical trials for HF excluded the patients with end-stage renal disease(ESRD).Few HF studies involved patients with ESRD.This review focuses on the study results relating to the treatment of HF and the feasibility of clinical application in ESRD patients.