加减地黄饮子治疗脑血栓形成恢复期患者对MAS和NIHSS评分的影响

Effect of Modified Dihuang Yinzi on MAS and NIHSS in the treatment of patients with cerebral thrombosis in recovery stage

目的探讨加减地黄饮子治疗脑血栓形成恢复期患者对MAS和NIHSS评分的影响。方法将2018年1月至2020年12月在我院神经内科治疗的80例脑血栓形成恢复期患者随机分为两组,对照组使用常规西药治疗,在此基础上,观察组使用加减地黄饮子治疗,对比两组的临床疗效、卒中病人运动评分标准(MAS)和美国国立卫生院神经功能缺损评分(NIHSS)变化、日常生活能力量表(ADL)及Brunel平衡量表(BBA)变化、中医证候积分变化、炎性因子及神经因子水平变化。结果观察组治疗有效率为95.00%,明显高于对照组的75.00%(P<0.05);观察组治疗后NIHSS评分明显低于对照组,MAS评分、ADL评分、BBA评分明显高于对照组(P<0.05);观察组治疗后半身不遂、言语謇涩、口舌歪斜、腰膝酸软、眩晕耳鸣、肢体麻木等中医证候积分明显低于对照组(P<0.05);观察组治疗后肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、血清胱抑素C(Cys-C)、神经元特异性烯醇化酶(NSE)水平明显低于对照组,而脑源性神经营养因子(BDNF)水平明显高于对照组(P<0.05)。结论加减地黄饮子治疗脑血栓患者形成恢复期的效果显著,能促进受损神经功能的修复,改善运动功能,减轻中医证候,降低机体炎症反应程度,促进病情的恢复,具有积极的临床意义。

Objective To investigate the effect of Modified Dihuang Yinzi on MAS and NIHSS scores in the treatment of patients with cerebral thrombosis in recovery period.Methods From January 2018 to December 2020,80 patients with cerebral thrombosis in recovery period treated in the Department of Neurology of our hospital were randomly divided into two groups.The control group was treated with conventional western medicine.On this basis,the observation group was treated with Modified Dihuang Yinzi.The clinical efficacy,the movement score standard(MAS)of stroke patients,the changes of the National Institutes of Health Neurological Impairment Score(NIHSS),the ability of daily living(ADL)and the Brunel Balance Scale(BBA)Changes,changes in TCM syndrome scores,changes in inflammatory factors and neurological factors levels of the two groups were compared.Results The effective rate of treatment in the observation group was 95.00%,which was significantly higher than 75.00% in the control group(P<0.05).The NIHSS score of the observation group after treatment was significantly lower than that of the control group,and the MAS score,ADL score,and BBA score were significantly higher than the control group(P<0.05).The scores of TCM syndromes in the observation group after treatment,such as hemiplegia,astringent speech,crooked tongue,waist and knee weakness,dizziness,tinnitus,and limb numbness,were significantly lower than those in the control group(P<0.05).The tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),serum cystatin C(Cys-C),neuron-specific enolase(NSE)levels after treatment were significantly lower than those of the control group,while the level of BDNF was significantly higher than that of the control group(P<0.05).Conclusion Modified Dihuang Yinzi has a significant effect in the treatment of patients with cerebral thrombosis during the recovery period.It can promote the repair of damaged nerve function,improve motor function,reduce TCM syndromes,reduce the degree of inflammation in the body,and promote the recovery of the disease.It has a positive clinical significance.