盐酸帕罗西汀结合小剂量非典型抗精神病药物在老年抑郁症患者中的应用价值

Application value of paroxetine acid combined with low-dose atypical antipsychotics in elderly patients with depression

目的为了了解老年抑郁症患者的治疗方法,本次研究将盐酸帕罗西汀结合小剂量非典型抗精神病药物作为治疗方案,以探究其效果。方法选取2019年1—12月我院92例老年抑郁症患者为研究对象。采用随机数字表法将其分为对照组和试验组,每组各46例。其中对照组患者选择帕罗西汀治疗,试验组患者选择帕罗西汀+小剂量非典型抗精神病药物(奥氮平)治疗。治疗8周后观察两组的总有效率、生存质量量表(HOQOL-BREF)评分、焦虑自评量表(SAS)评分、汉密尔顿抑郁量表(HAMD-17)评分以及不良反应量表评分。结果试验组患者的总有效率(100.00%)高于对照组(73.91%),差异有统计学意义(P<0.05)。两组治疗前的HOQOL-BREF评分、SAS评分、HAMD-17评分比较,差异无统计学意义(P>0.05),两组治疗后HOQOL-BREF、SAS及HAMD-17评分比较,差异有统计学意义(P<0.05)。两组不良反应量表评分比较,差异无统计学意义(P>0.05)。结论老年抑郁症患者在选择治疗方法上,可以将帕罗西汀+奥氮平考虑在内,能有效提高患者的生存质量,值得应用。

Objective To investigate the effect of paroxetine hydrochloride combined with low-dose atypical antipsychotics in the treatment of elderly patients with depression.Methods Ninety-two elderly patients with depression treated in our hospital from January 2019 to December 2019 were selected.They were divided into the control group and the experimental group using the random number table method,with 46 patients in each group.The control group were treated with paroxetine,and the experimental group were treated with paroxetine combined with low-dose atypical antipsychotics(olanzapine).The differences in the total effective rate,quality of life scale(HOQOL-BREF)score,anxiety self-rating scale(SAS)score,Hamilton depression scale(HAMD-17)score and adverse event scale score were compared between the two groups after 8 weeks of treatment.Results The total effective rate of patients in the experimental group(100.00%)was higher than that in the control group(73.91%),with statistically significant difference(P<0.05).There were no statistically significant differences in the HOQOL-BREF score,SAS score,and HAMD-17 score between the two groups before treatment(P>0.05).There were no statistically significant differences in the HOQOL-BREF score,SAS score and HAMD-17 score between the two groups after treatment(P<0.05).There was no statistically significant difference in the adverse event scale score between the two groups(P>0.05).Conclusion Paroxetine combined with olanzapine can be considered as the treatment for elderly patients with depression.It can effectively improve the quality of life of patients and is worthy of application.