摘要
目的:探讨血清IL-17A与干扰素γ诱导蛋白10(IP-10)在原发性肝癌中的表达及临床意义。方法:收集2015年1月至2017年12月我科收治的原发性肝癌患者182例(实验组)及健康体检者50例(对照组),检测两组受试者血清IL-17A、IP-10值,比较两组血清IL-17A、IP-10水平差异,分析血清IL-17A、IP-10对原发性肝癌早期诊断的预测价值。结果:实验组患者术前血清IL-17A、IP-10水平分别高于对照组血清IL-17A、IP-10水平(P<0.05);实验组患者术后血清IL-17A、IP-10水平分别低于实验组患者术前血清IL-17A、IP-10水平(P<0.05);原发性肝癌患者不同病理组织分型间血清IL-17A、IP-10水平相比,差异具有统计学意义(P<0.05);原发性肝癌Ⅲ期患者的血清IL-17A、IP-10水平分别高于原发性肝癌Ⅰ、Ⅱ期患者的血清IL-17A、IP-10水平(P<0.05)。多因素分析结果示:血清TBil、AST、ALT、AFP、IL-17A、IP-10水平升高是原发性肝癌发生的独立危险因素。ROC曲线示:血清IL-17A曲线下面积为0.793,敏感度和特异度分别为0.827和0.619;IP-10曲线下面积为0.757,敏感度和特异度分别为0.796和0.714;血清IL-17A、IP-10联合检测曲线下面积为0.883,敏感度和特异度分别为0.898和0.810。结论:血清IL-17A、IP-10水平升高在原发性肝癌病情进展中起重要作用,可作为原发性肝癌早期诊断预测指标之一。
Objective:To investigate the expression and clinical significance of serum IL-17A and interferon gamma-inducible protein 10(IP-10)in primary liver cancer.Methods:A total of 182 patients with primary liver cancer(experimental group)and 50 healthy subjects(control group)were enrolled from January 2015 to December 2017.The serum levels of IL-17A and IP-10 were detected in the two groups.The difference of serum IL-17A and IP-10 levels between the two groups was compared,and the predictive value of serum IL-17A and IP-10 for early diagnosis of primary liver cancer was analyzed.Results:The preoperative levels of serum IL-17A,IP-10 in the experimental group was higher than that of serum IL-17A and IP-10 in the control group(P<0.05).The postoperative levels of serum IL-17A and IP-10 in the experimental group were lower than those preoperative levels of serum IL-17A and IP-10 in the experimental group(P<0.05).There were significant differences in serum IL-17A and IP-10 levels between different pathological tissue types of patients with primary liver cancer(P<0.05).The levels of serum IL-17A and IP-10 in stageⅢof primary liver cancer were higher than that of serum IL-17A and IP-10 in stageⅠandⅡof patients with primary liver cancer(P<0.05).Multivariate analysis showed that elevated serum TBil,AST,ALT,AFP,IL-17A,and IP-10 levels were indenpendent risk factors for primary liver cancer.The ROC curve showed that the area under the serum IL-17A curve was 0.793,and the sensitivity and specificity were 0.827 and 0.619,respectively.The area under the IP-10 curve was 0.757,and the sensitivity and specificity were 0.796 and 0.714,respectively.The area under the serum IL-17A combined with IP-10 was 0.883,and the sensitivity and specificity were 0.898 and 0.810,respectively.Conclusion:The elevated levels of serum IL-17A and IP-10 play an important role in the progression of primary liver cancer,and can be used as one of the early diagnostic indicators for primary liver cancer.
作者
李玮
谢友利
刘雅娟
吴兰梅
LI Wei;XIE Youli;LIU Yajuan;WU Lanmei(Hepatobiliary and Pancreatic Surgery,Central South Hospital of Wuhan University,Hubei Wuhan 430071,China)
出处
《现代肿瘤医学》
CAS
北大核心
2021年第18期3228-3232,共5页
Journal of Modern Oncology