基于动态增强MRI影像组学参数的观察者一致性研究

Observer consistency study based on dynamic enhanced MRI radiomics parameters

目的:基于动态增强磁共振成像(magnetic resonance imaging,MRI),探讨不同观察者人工勾画三维感兴趣区(region of interest,ROI)所获影像组学参数的一致性。方法:选取复旦大学附属肿瘤医院收治的确诊为乳腺癌的患者62例。应用ITK-SNAP图像勾画软件对肿瘤进行三维ROI病灶勾画。提取ROI内肿瘤的形态学特征参数和一阶参数,而后对其进行一致性检验。结果:在整体肿瘤中,观察者间与观察者内均具有较高的一致性(α>0.75),且观察者内一致性(α均>0.9)高于观察者间(α均>0.8)。按照肿瘤强化形态将其分为肿块样和非肿块样强化,发现形态学特征参数一致性较好,而一阶参数峰值、最小值的一致性检验结果<0.75。在不同T分期肿瘤中,T_(1)+T_(2)期肿瘤一阶参数峰值、偏度的一致性检验结果<0.75,并且T_(1)+T_(2)期肿瘤的α值普遍低于T3期。结论:不同观察者间影像组学参数一致性较高,这是对既往相关研究结果可靠性的进一步证实;部分一阶参数的一致性在不同T分期、不同强化形态肿瘤间仍较不可观,需扩大样本量进一步分层分析。

Objective:Based on dynamic enhanced magnetic resonance imaging(MRI),to explore the consistency of radiomics parameters obtained by different observers manually delineating region of interest(ROI).Methods:A total of 62 patients with breast cancer diagnosed in Fudan University Shanghai Cancer Center were selected.The ITK-SNAP software was used to the threedimensional lesion delineation.The morphological characteristic and first-order parameters in the ROI were extracted,and then the consistency test was carried out.Results:In the overall tumors,there were a higher inter-observer and intra-observer agreement(α>0.75),and the intra-observer agreement(all α>0.9)was higher than inter-observer’s(all α>0.8).When we divided tumors into mass-like and nonmass-like enhancement according to the tumor enhancement morphology,we found that the consistency of the morphological parameters was well(all α>0.75),but the consistency of peak and minimum values of the first-order parameter were less than 0.75.Among tumors of different T stages,the consistency of the first-order parameter peak and skewness of T_(1)+T_(2) tumors are less than 0.75,and the α value of T_(1)+T_(2) tumors was generally lower than that of T3 tumors.Conclusion:The consistency of the radiomics parameters between different observers is relatively high,which is a further confirmation of the reliability of the results of previous related studies.The consistency is still not appreciable among tumors with different T stages and different enhancement forms among some first-order parameters.Therefore,the sample size should be expanded for further stratified analysis.