CD4^(+)T细胞介导调控神经炎症在神经退行性疾病中的研究进展

Research Progress of CD4^(+) T Cells-mediated Regulation ofNeuroinflammation Involved in Neurodegenerative Diseases

神经退行性疾病是一类与神经炎症、氧化应激、衰老等多种因素有关的疾病,可导致认知及运动功能障碍。近年多项研究提示神经退行性疾病的发生发展与适应性免疫反应有关,CD4^(+)T细胞作为适应性免疫细胞参与其中。CD4^(+)T细胞可根据不同的途径分化成不同的功能亚群,包括辅助性T细胞亚群及调节性T细胞亚群等,不同亚群可对阿尔茨海默病、帕金森病、多发性硬化症和肌萎缩性侧索硬化症等神经退行性疾病进展产生不同的调节作用。本文主要综述CD4^(+)T细胞在神经退行性疾病发病过程中的作用及研究进展。

Neurodegenerative diseases are associated with neuroinflammation,oxidative stress,and aging,which can lead to cognitive and motor dysfunctions.Recent studies suggest that the development of neurodegenerative diseases is related to adaptive immunity,in which CD4^(+)T cells are involved as adaptive immune cells.Through different pathways,CD4^(+)T cells differentiate into effector and regulatory subsets,which may have different effects on the progression of neurodegenerative diseases such as Alzheimer’s disease,Parkinson’s disease,multiple sclerosis,and amyotrophic lateral sclerosis.Here,we review the role and research progress of CD4^(+)T cells in neurodegenerative diseases.