外泌体在中医药研究中的应用进展

Advances in the application of exosomes in traditional Chinese medicine

外泌体富含传导细胞通讯活性的基因组和非基因组生物分子。其广泛存在于人体的体液中,不仅参与了全身多系统疾病的致病过程,还可作为治疗剂和药物递送的媒介,因此被称为“天然药物载体”。中医药通过调控外泌体来发挥其靶向调控、远距离传输的治疗作用。本文综述了外泌体在中医心血管疾病、肝脏疾病、呼吸系统疾病及肿瘤系统疾病中的应用进展,为中医药的研究提供新的思路。

Exosomes are rich in genomic and non-genomic biomolecules that conduct cell communication activity.It is widely present in the body fluids,not only participates in the pathogenesis of systemic multi-system diseases,but also can be used as therapeutic agent and drug delivery media,so it is called“natural drug carrier”.Traditional Chinese medicine plays its therapeutic role of targeted regulation and long-distance transmission by regulating exosomes.This paper reviews the application of exosomes in cardiovascular disease,liver disease,respiratory system disease and tumor system disease in traditional Chinese medicine,providing new ideas for the research of traditional Chinese medicine.