氨溴索联合N-乙酰半胱氨酸对新生儿肺炎的效果及超声评分变化分析

Analysis of the effect of Ambroxol combined with N-acetylcysteine on neonatal pneumonia and changes in ultrasound scores

目的观察氨溴索联合N-乙酰半胱氨酸治疗新生儿肺炎的临床效果及超声评分的变化。方法选择2016年2月至2019年7月江苏省苏州市第九人民医院收治的150例新生儿肺炎患儿作为研究对象,采用随机数字表法分为研究组和对照组,每组75例。两组均给予基础治疗+氨溴索治疗,研究组加用N-乙酰半胱氨酸治疗,两组均治疗7 d。比较两组治疗前后的外周血白细胞计数(WBC)、超敏C反应蛋白(hs-CRP)、降钙素原(PCT),白细胞介素(IL)-2、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))水平及超声评分。结果治疗7 d后,研究组PaO_(2)高于对照组,hs-CRP、PCT、超声评分低于对照组(P<0.05)。研究组发热、咳嗽、干湿啰音、气喘的缓解时间短于对照组(P<0.05)。研究组总有效率高于对照组(P<0.05)。治疗过程中,两组患儿均未出现严重的不良反应。结论氨溴索联合N-乙酰半胱氨酸治疗新生儿肺炎安全有效,对于改善患儿临床症状、减轻炎症反应具有积极作用。

Objective To observe the clinical effect of Ambroxol combined with N-acetylcysteine on neonatal pneumonia and the change of ultrasound scores.Methods A total of 150 neonatal pneumonia admitted to Suzhou Ninth People’s Hospital in Jiangsu Province from February 2016 to July 2019 were selected as the research subjects,they were divided into study group and control group,with 75 cases in each group.Both groups were given basic treatment+Ambroxol treatment,children in study group were treated with N-acetylcysteine for treatment.Both groups were treated for 7 days.The levels of peripheral blood white blood cell count(WBC),hypersensitive C-reactive protein(hs-CRP),procalcitonin(PCT),interleukin(IL)-2,arterial partial pressure of oxygen(PaO_(2)),partial pressure of carbon dioxide in artery(PaCO_(2)),and ultrasound scores were compared between two groups before and after treatment.Results After 7 days of treatment,PaO_(2) of study group was higher than that of control group,while hs-CRP,PCT,and ultrasound scores were lower than those of control group(P<0.05).The remission time of fever,cough,dry and wet rales,and asthma in study group were shorter than those in control group(P<0.05).The total effective rate in study group was higher than that in control group(P<0.05).During the treatment,no serious adverse reactions occurred in two groups.Conclusion Ambroxol combined with N-acetylcysteine is safe and effective in the treatment of neonatal pneumonia,and has a positive effect on improving clinical symptoms and reducing inflammation in children.