乳腺癌中Cyclin D1和TGF-β_(1)蛋白表达及其临床意义

The Expression of Cyclin D1 and TGF-β_( 1) in Breast Cancer and Their Clinical Significance

目的探讨细胞周期蛋白D1(Cyclin D1)和转化生长因子β_( 1)(TGF-β_( 1))在乳腺癌组织中的表达,并分析二者的表达与乳腺癌临床病理特征的关系。方法采用免疫组化Max Vision法检测86例乳腺癌、60例正常乳腺组织和60例乳腺良性增生组织中Cyclin D1和TGF-β_( 1)蛋白表达。结果乳腺癌组织中Cyclin D1和TGF-β_( 1)蛋白的表达阳性率高于正常乳腺组织及乳腺良性增生组织(P<0.05)。Cyclin D1和TGF-β_( 1)蛋白表达与乳腺癌患者年龄、绝经状态、肿瘤直径及组织学分类均无关,而与患者淋巴结转移及临床分期有关(P<0.05)。乳腺癌中Cyclin D1蛋白表达强度和TGF-β_( 1)蛋白表达呈正相关(P<0.05)。结论Cyclin D1和TGF-β_( 1)蛋白在乳腺癌的发展转移中发挥重要作用,并可为乳腺癌靶向治疗及预后判断提供可靠依据。

Objective To explore the expression of Cyclin D1 and transforming growth factor-β_( 1)(TGF-β_( 1))protein in breast cancer,and analyze their relationship with the clinical pathologic characteristics.Methods The expression of cyclin D1 and TGF-β_( 1) protein in 86 breast cancer tissues,60 normal breast tissues and 60 benign hyperplasia tissues were detected by immunohistochemical method.Results The expression of Cyclin D1 and TGF-β_( 1) in breast cancer were higher than that in normal breast tissues and benign hyperplasia tissues(P<0.05).The expression of Cyclin D1 and TGF-β_( 1) were not correlated with age,menopausal status,the tumor size and histological types,but correlated with the lymph node metastasis and clinical stages(P<0.05).Conclusion Cyclin D1 and TGF-β_( 1) play an important role in the development,metastasis of breast cancer,and it can provide reliable basis for targeted therapy and prognosis judgement of breast cancer.