银屑病与高血压病相关性的meta分析

Meta analysis of correlation between psoriasis and hypertension

目的系统评价银屑病与高血压病的相关性。方法检索中国知网、万方数据库、维普网、中国生物医学网、PubMed、Cochrane及Embase,筛选关于银屑病与高血压相关性的文献资料,检索时间为建库至2020年10月。由2名研究者独立筛选文献、提取资料,并对文献进行质量评估,采用Stata 16.0版软件进行meta分析。结果共纳入35篇文献,meta分析结果显示银屑病组高血压患病率明显的高于对照组,差异有统计学意义(OR=1.75,95%CI:1.58~1.94,P<0.001)。轻度(OR=1.27,95%CI:1.24~1.30c,P<0.001)、重度银屑病组(OR=1.54,95%CI:1.24~1.89,P<0.001)高血压患病率均高于对照组。按照发表地区进行亚组分析显示,各地区银屑病组高血压患病率均高于对照组,差异有统计学意义(P<0.05)。结论在目前数据支持下,无论银屑病严重程度,其与高血压患病率均有相关性,提示银屑病可能增加高血压病的患病风险。

Objective To systematically evaluate the correlation between psoriasis and hypertension.Methods Relevant literatures about the correlation between psoriasis and hypertension published from inception to October 2020 were searched from CNKI,Wanfang Data,VIP,CBM,PubMed,Cochrane and Embase.Two investigators were independently responsible for screening literatures,extracting data and assessing the quality.The software version 16.0 of Stata was used for meta analysis.Results A total of 35 literatures were included.Meta-analysis results showed that the prevalence of hypertension in the psoriasis group was significantly higher than that in the control group,and the difference was statistically significant(OR=1.75,95%CI:1.58-1.94,P<0.001).The prevalence of hypertension in mild(OR=1.27,95%CI:1.24-1.30,P<0.001)and severe psoriasis group(OR=1.54,95%CI:1.24-1.89,P<0.001)was higher than that in control group.Subgroup analysis according to published regions showed that the prevalence of hypertension in the psoriasis group was higher than that in the control group in all regions,with statistical significance(P<0.05).Conclusion Under the current data support,regardless of the severity of psoriasis,psoriasis is correlated with the prevalence of hypertension,suggesting that psoriasis may increase the risk of hypertension.