基于数据挖掘方法探究中药改善子宫内膜容受性的用药规律

Exploring the rule of traditional Chinese medicine in improving endometrial receptivity based on data mining method

目的通过数据挖掘方法探究中药改善子宫内膜容受性的用药规律。方法对2010年1月至2020年6月在中国知网、万方数据库、维普中文科技期刊数据库发表的有关中药改善子宫内膜容受性的文献资料进行整理,用Excel及SPSS统计软件进行中药、药味、药性、归经频次统计、关联规则分析和聚类分析。结果共纳入110首处方,涉及中药142味,频数最高的药物是菟丝子。药味以甘、苦、辛为主,药性上多选用温、平类药物,主归肝、脾、肾经。得到核心药物组合21种,4个聚类方。结论改善子宫内膜容受性以补益肝肾,调理气血为主,应重视肝肾,兼顾脾胃。

Objective To explore the rule of traditional Chinese medicine in improving endometrial receptivity through data mining method.Methods The literatures on the improvement of endometrial receptivity by traditional Chinese medicine published on CNKI,Wanfang database and VIP from January 2010 to June 2020 were collected,and the statistics of traditional Chinese medicine,drug flavor,drug properties,frequency of channel tropism,association rule analysis and cluster analysis were performed by Excel and SPSS statistical software.Results A total of 110 prescriptions were included,involving 142 kinds of traditional Chinese medicine.The most frequent drug was dodder seed.The drug flavor is mainly sweet,bitter,and pungent.In terms of drug properties,warm and flat drugs were mostly used,which mainly belong to the liver,spleen and kidney channels.A total of 21 core drug combinations and four cluster formulae were obtained.Conclusion The improvement of endometrial receptivity is mainly tonifying and replenishing liver and kidney and regulating qi and blood.The liver and kidney should be paid attention to while the spleen and stomach should be taken into account.