骨质疏松症与慢性心力衰竭的关系

Relationship between osteoporosis and chronic heart failure

目的基于生物信息学方法探讨骨质疏松症与慢性心力衰竭的关系。方法分别以骨质疏松及慢性心力衰竭在相关人类疾病数据库(Gene Cards、TTD、OMIM)中筛选靶基因,整合后映射两组预测靶点得到交集靶点,通过STRING v11.0平台得出靶点PPI互作网络,按照degree值大小筛选出核心靶点并通过Metascape数据库进行KEGG通路分析。结果骨质疏松症与慢性心力衰竭的核心交集靶点为VEGFA、STAT3、IL6、TNF、ESR1、IL10等,相关通路集中在PI3K-Akt信号通路、FoxO信号通路、HIF-1信号通路、MAPK信号通路等。结论骨质疏松症与慢性心力衰竭均是涵盖众多差异表达基因的复杂慢性病,但两种疾病在复杂基因网络背景下依然存在一些高度重合的基因表达,所涉及的信号通路能够同时对两种疾病产生干预作用,这提示两种疾病的分子机制存在密切联系,可能为药物同时调控两种疾病提示潜在靶点。应用生物信息学具有较高的置信度和参考价值,为探索疾病间关系提供了新方向与新思路。

Objective To investigate the relationship between osteoporosis and chronic heart failure based on bioinformatics method.Methods The target genes were screened in related human disease databases(GeneCards,TTD,OMIM)with osteoporosis and chronic heart failure respectively,and the two sets of predicted targets were mapped to obtain the intersection targets.The PPI interaction network of targets was obtained through STRING v11.0 platform.The core targets were selected according to the degree value,and KEGG pathway analysis were carried out through M etascape database.Results The core intersection targets of osteoporosis and chronic heart failure are VEGFA,STAT3,IL6,TNF,ESR1,IL10,etc.The related pathways are concentrated in the PI3K-Akt signaling pathway,FoxO signaling pathway,HIF-1 signaling pathway,MAPK signaling Access etc.Conclusion Both osteoporosis and chronic heart failure are complex chronic diseases that cover many differentially expressed genes.However,the two diseases still have some highly overlapping gene expressions under the background of complex gene networks,and the signal pathways involved can simultaneously treat the two diseases.These result suggest that the molecular mechanisms of the two diseases are closely related and may suggest potential targets for drug regulation of both diseases at the same time.The application of bioinformatics has high confidence and reference value,which provides a newdirection and newidea for exploring the relationship between diseases.