从线粒体未折叠蛋白反应探讨补肾益精法治疗慢传输型便秘机制的研究思路

Research Thinking on the Mechanism of Tonifying Shen and Nourishing Essence in the Treatment of Slow Transit Constipation from Mitochondrial Unfolded Protein Response

慢传输型便秘的发病机制与线粒体内累积大量错误或未折叠蛋白引起的线粒体功能受损,进而引发肠神经系统(ENS)-Cajal间质细胞(ICC)-平滑肌细胞(SMC)网络结构损伤最终导致肠道动力紊乱有关。现代医学脑-肠轴的提出证实了人体大脑对肠道具有调节作用,而中医学补肾益精法是治疗脑神经退行性病变和慢传输型便秘的常用治法,笔者认为补肾益精法可能通过调控海马神经元线粒体未折叠蛋白反应通过脑-肠轴影响到结肠细胞线粒体未折叠蛋白反应,进而调节肠道动力治疗慢传输型便秘。笔者拟以线粒体未折叠蛋白反应为切入点,为探究补肾益精法从脑治肠治疗慢传输型便秘机制提供新的研究思路。

The pathogeneses of slow transit constipation(STC) are related to the impairment of mitochondrial functions caused by the accumulation of a large number of errors or unfolded proteins in the mitochondria, which leads to the damage of enteric nervous system(ENS)-interstitial cells of Cajal(ICC)-smooth muscle cells(SMC) network structure, and finally results in intestinal motility disorder. The proposal of the braingut axis in modern medicine has confirmed that the human brain has a regulatory effect on the intestinal tract, and the method of tonifying Shen and tonifying essence(TSTE) in traditional Chinese medicine is a common treatment method for cerebral neurodegeneration and STC. Then TSTE method might affect the unfolded protein response of colon cells mitochondria through brain-gut axis, thus regulating intestinal dynamics in the treatment of STC. The mechanisms of TSTE for the treatment of STC were studied based on the reactions of mitochondrial unfolded protein, thus providing a new research idea and molecular mechanisms for the treatment of intestinal disease from the brain in this paper.