子宫内膜癌表观扩散系数与肿瘤生长状态的相关性分析

The correlation analysis of the apparent diffusion coefficient of endometrial carcinoma and tumor growth status

目的探讨子宫内膜癌表观扩散系数(ADC)与肿瘤生长状态的相关性。方法回顾性收集82例子宫内膜样腺癌患者的临床病理资料,所有患者均进行3.0T常规MRI和扩散加权成像(DWI)检查,由两位放射科医生分别独立评估所有序列图像,并在磁共振机器配套的diffusion软件包上进行ADC测量,将测得的ADC值在肿瘤组织学分级、肌层浸润深度、淋巴结状态、子宮内膜状态、是否侵犯结合带等层面进行比较。结果肿瘤组织学分级G1、G2、G3级的ADC值,两名阅片人比较均存在统计学差异(P<0.001),不同肿瘤侵犯深度的ADC值无统计学差异(P1=O.577,P2=0.599),淋巴结转移状态(P1=0.17,P2=0.761)、子宫内膜厚度(P1=0.22,P2=0.25)、是否侵犯结合带(P1=0.49,P2=0.39)的ADC值均无统计学差异。结论子宫内膜癌术前测量ADC值可以初步评估肿瘤的病理分化程度,指导制定治疗方案和预测预后。

Objective To investigate the correlation between the apparent diffusion coefficient(ADC)of endometrial cancer and tumor growth status.Methods The clinicopathological data of 82 patients with endometrioid adenocarcinoma was collected retrospectively.All patients underwent 3.0T routine MRI and diffusion-weighted imaging(DWI)examinations.The ADC measurement was performed on the difiusion software package of the resonance machine,and the measured ADC values were compared at the levels of tumor histological grade,muscle layer infiltration depth,lymph node status,endometrial status,and whether it invaded the junction zone.Results The ADC values of tumor histological grades G1,G2,and G3 were statistically difierent between the two readers(P<0.001),and there was no statistical difference in ADC values of diflerent tumor invasion depths(P1=0.577,P2=0.599),lymph node metastasis status(P1=O.17,P2=0.761),endometrial thickness(P1=0.22,P2=0.25),and whether it invaded the conjugation zone(Pl=0.49,P2=0.39),the ADC values were not statistically difierent.Conclusion Preoperative measurement of ADC value for endometrial cancer can preliminarily assess the degree of pathological differentiation of the tumor,guide the formulation of treatment plans and predict prognosis.