改良电抽搐治疗对双相障碍抑郁发作患者记忆力的影响

目的探讨改良电抽搐治疗(MECT)对双相障碍抑郁发作患者记忆功能的影响。方法42例双相障碍抑郁发作临床诊断的患者在常规药物治疗基础上联合MECT治疗,分别在治疗前、治疗后1天、治疗后2周、治疗后4周采用修订韦氏记忆量表(WMS-RC)评定患者的记忆力水平。结果MECT治疗结束后1天,患者的MQ和各项因子评分均较治疗前有所降低,差异有统计学意义(P<0.05);治疗结束后2周,患者的MQ和各因子评分与治疗前比较,均已接近或超过治疗前评分,差异无统计学意义(P>0.05);治疗结束后4周,患者的MQ和各因子评分均明显大于治疗前,差异有统计学意义(P<0.05)。结论MECT对患者记忆力有暂时性影响,可在治疗结束2~4周内恢复至病前水平。

Objective To investigate the efiect of modified electroconvulsive therapy(MECT)on memory function of bipolar depressive patients.Methods 42 cases of patients with bipolar disorder clinically diagnosed with depressive episodes were treated with MECT on the basis of conventional drug treatment.The revised Wechsler Memory Scale(WMS-RC)was used before treatment,1 day after treatment,2 weeks after treatment,and 4 weeks after treatment to assess the patient's memory level.Results One day after the end of MECT treatment,the patient's MQ and various factor scores were lower than before treatment,and the diHerence was statistically significant(P<0.05).2 weeks after the end of treatment,the patient's MQ and various factor scores were the same as those before treatment in comparison,the scores were close to or exceeded the pre-treatment score,and the difference was not statistically significant(P>0.05).4 weeks after the treatment,the patient's MQ and each factor score were significandy greater than those before the treatment,and the difierence was statistically significant(P<0.05).Conclusion ECT has a temporary efiect on the patient's memory,which can be restored to the pre-disease level within 2 to 4 weeks after the treatment.