快速检测试剂条联合血常规检测在疟疾诊断中的初筛价值

Preliminary screening value of rapid detection reagent strip combined with routine blood test in diagnosis of malaria

目的通过对疟疾快速检测试剂条(RDT)、血常规和疟原虫镜检结果进行分析,研究RDT联合血常规检测在疟疾诊断中的初筛价值。方法对本院2016年6月—2019年6月临床申请进行RDT、血常规及疟原虫镜检的887份血样结果进行回顾性分析,选取发热患者和健康体检者血常规结果各30份予以比较。结果887份血样中RDT阳性21份,阳性率为2.37%;镜检阳性14份,阳性率为1.58%;RDT和镜检均阳性14份;两者差异无统计学意义(P>0.05)。疟疾组WBC与发热组比较差异有统计学意义(P<0.05),疟疾组WBC与体检组比较差异无统计学意义(P>0.05);疟疾组RBC、HGB、RDW、PLT与发热组、体检组比较差异有统计学意义(P<0.05)。14例疟疾患者血常规基本参数中,RBC、HGB减低7例(50.00%),RDW增高6例(42.86%),PLT降低8例(57.14%),患者存在出现一种或多种变化情况。结论RDT联合血常规检测结果对疟疾诊断具有初筛价值。

Objective Through analyzing the results of rapid detection reagent strip(RDT),blood routine examination and plasmodium microscopic examination,the preliminary screening value of RDT combined with blood routine examination in diag⁃nosis of malaria was studied.Methods From June 2016 to June 2019,887 blood samples from clinical applications in our hos⁃pital were analyzed retrospectively,including RDT,blood routine examination and plasmodium microscopic examination.30 blood routine examination results of fever patients and 30 blood routine examination results of healthy people were selected for comparative analysis.Results Of 887 blood samples tested,21 were RDT positive,with the positive rate of 2.37%;14 were microscopy positive,with a positive rate of 1.58%;14 were both RDT and microscopy positive;there was no statistical signifi⁃cance on the difference between the two groups(P>0.05).There was statistical significance on the difference between malaria group WBC and fever group(P<0.05),there was no statistical significance on the difference between malaria group WBC and physical examination group(P>0.05);there was statistical significance on the differences of RBC,HGB,RDW,PLT between malaria group,fever group and physical examination group(P<0.05).Among the basic blood routine parameters of 14 malaria patients,RBC and HGB decreased in 7 cases(50.00%),RDW increased in 6 cases(42.86%),PLT decreased in 8 cases(57.14%),one or more changes were observed in patients.Conclusion RDT combined with blood routine test results have primary screening value for malaria diagnosis.