摘要
药物共晶具有调节活性药物成分理化特性的潜力,作为一种可替代活性药物成分的固态形式日益受到关注。针对这一热点问题,研究者们提出了一些新的合成策略和表征技术。基于近10年来药物共晶的研究进展,分别阐述了药物共晶的形成原理、制备方法、表征技术、理化性质和应用前景,介绍了一些新兴技术的应用,并分析了部分研究案例,着重介绍了关于药物共晶的熔点、溶解度、溶出速率、生物利用度、稳定性及机械性能等理化性质的研究。本文旨在归纳总结药物共晶的最新研究进展,为其进一步发展提供参考。
Pharmaceutical cocrystals have the potential to adjust the physicochemical properties of active pharmaceutical ingredient(API),and have attracted increasing attention as the alternative solid forms of APIs.New synthetic strategies and advanced characterization techniques have been proposed in this hot research topic by researchers.On the basis of the research progress of pharmaceutical cocrystals over the last decade,the formation principles,preparation methods,characterization techniques,physicochemical properties and application prospects are described respectively,some research cases are also introduced.This review focuses on melting point,solubility,dissolution rate,bioavailability,stability and mechanical properties of pharmaceutical cocrystals,and summarizes the latest research progress,hoping to provide some references for the further development of pharmaceutical cocrystals.
作者
王礼丽
高紫尧
刘书妤
WANG Lili;GAO Ziyao;LIU Shuyu(School of Chemistry and Chemical Engineering,Shanghai University of Engineering Science,Shanghai 201620)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2021年第7期881-890,共10页
Chinese Journal of Pharmaceuticals
关键词
活性药物成分
共晶
理化性质
制备
表征
active pharmaceutical ingredient
cocrystal
physicochemical property
preparation
characterization
