血管生成抑制因子l和血管内皮生长因子A在胃癌组织中的表达及其临床意义

Expression of vasohibin-1 and VEGF-A and its clinical significance in gastric cancer

目的探讨血管生成抑制因子1(VASH1)和血管内皮生长因子A(VEGF-A)蛋白在胃癌组织中的表达及其临床意义。方法应用免疫组化方法检测56例胃癌及癌旁组织中VASH1和VEGF-A蛋白的表达,分析二者相关性,并明确VASH1与胃癌患者临床病理指标及预后的关系。结果胃癌组织中VASH1和VEGF-A蛋白的表达比癌旁正常组织中的表达明显增高;胃癌组织中VASH1蛋白表达阳性率为79%,VEGF-A蛋白表达阳性率为82%,二者具有显著正相关性(r=0.77,P<0.01)。VASH1蛋白表达与胃癌TNM分期、浸润深度、大体类型及远处转移均有关(均P<0.05),而与患者年龄、性别、肿瘤分化程度及有无淋巴转移均无关(均P>0.05)。VASH1蛋白高表达的胃癌患者预后明显差[总生存时间:(24.56±5.05)个月比(57.09±4.83)个月,P<0.01;无疾病进展生存时间:(22.74±4.55)个月比(56.46±5.02)个月,P<0.01]。结论VASH1高表达与肿瘤的浸润、转移及不良预后密切相关,可能是胃癌预后判断的重要指标。

Objective To explore the expression of vasohibin-1(VASH1)and vascular endothelial growth factor A(VEGF-A)and clinical significance of VASH1 in gastric carcinoma.Methods The expression of VASH1 and VEGF-A were detected by immunohistochemistry in formalin-fixed and paraffin-embedded sections in 56 pairs of gastric cancer and corresponding paraneoplastic tissue specimens.The correlation between the expression of VASH1,VEGF-A,clinicopathological parameters and prognosis were analyzed.Results VASH1 and VEGF-A expression was significantly higher in gastric cancer tissues than normal paraneoplastic tissues.VASH1 and VEGF-A protein were expressed in 79%and 82%of gastric cancer tissues,respectively.A positive correlation was found between Vasohibin-1 and VEGF-A expression in gastric cancer tissues.VASH1 expression has significant positive correlation with TNM stage,tumor stromal invasion,tumor gross types and distant metastasis.Patients with high VASH1 expression had significantly worse overall survival(OS)and progression-free survival(PFS)than those with low VASH1 expression.Conclusion VASH1 might be a clinically relevant predictor of patients in gastric cancer.