选择性胎儿生长受限胎儿预后研究进展

Outcome of twin fetuses with selective fetal growth restriction

单绒毛膜双胎中,10%~15%会发生选择性胎儿生长受限(selective fetal growth restriction,sFGR)。sFGR可通过脐动脉多普勒波形分为3种类型。sFGR胎儿宫内死亡的发生率高,出生胎龄小,可有脑损伤、心肌肥厚、右心室流出道梗阻、肠穿孔、胰岛素分泌异常等多系统不良预后,且不同分型的sFGR的临床特点及预后不同。目前针对该人群的研究较少。sFGR仍需全面、长期随访。

Selective fetal growth restriction(sFGR)occurs in about 10%to 15%of monochorionic twins with a high incidence of intrauterine fetal death and low gestational age at birth.sFGR is associated with multisystem adverse prognosis,including brain injury,myocardial hypertrophy,right ventricular outflow tract obstruction,intestinal perforation,and abnormal insulin secretion.sFGR can be classified into three types based on the umbilical artery Doppler waveforms under ultrasound.The clinical characteristics and prognosis vary with the different types.There are few reported studies on the sFGR population,and comprehensive,long-term follow-up is needed.