保妇康凝胶治疗老年阴道炎患者的临床研究

Clinical trial of Baofukang gel in the treatment of elderly patients with vaginitis

目的观察保妇康凝胶治疗老年阴道炎患者的临床研究。方法将76例老年阴道炎患者随机分为试验组38例和对照组38例。对照组予以己烯雌酚片置于阴道深处,每次0.25 mg,每天1~2次;试验组在对照组的基础上给予保妇康凝胶治疗,每次2 g,每天1次。2组均持续治疗14 d。比较2组患者的疗效、症状消失时间、阴道内清洁度、pH值及药物不良反应发生情况。结果治疗后,对照组和试验组有效率分别为78.95%,97.37%;分泌物减少时间分别为(10.89±2.16),(7.02±2.38)d;瘙痒灼热感消失时间分别为(7.95±1.63),(5.67±0.92)d;内壁充血消失时间分别为(13.57±3.46),(9.79±2.83)d;阴道清洁度级别分别为2.91±0.52,2.20±0.36;pH分别为5.62±0.40,5.22±0.27,差异均有统计学意义(均P<0.05)。试验组和对照组药物不良反应发生率分别为15.79%,13.16%,差异无统计学意义(P>0.05)。结论保妇康凝胶治疗老年性阴道炎可提高临床疗效,有效调节酸碱平衡度,改善阴道清洁度。

Objective To observe the clinical effect of Baofukang gel in the treatment of elderly patients with vaginitis. Methods A total of 76 elderly patients with vaginitis were randomly divided into treamtent group(n=38) and control group(n=38). Control group was given diethylstilestrol tablets deep in the vagina, 0.25 mg a time, 1-2 times a day, while treatment group was given Baofukang gel on the basis of control group, 2 g a time, once a day. Both groups were treatment for 14 d. The efficacy, symptom reduction time, vaginal cleanliness, pH value and adverse drug reactions were compared between the two groups. Results After treatment, the effective rate of control group and treamtent group were 78.95% and 97.37%;the duration of decrease in secretion were(10.89± 2.16),(7.02 ±2.38)d, the duration of disappearance of the itching and burning sensation were(7.95±1.63),(5.67±0.92)d, the disappearance time of intramural hyperemia were(13.57±3.46),(9.79±2.83)d, the vaginal cleanliness levels were 2.91±0.52,2.20±0.36, the pH levels were 5.62±0.40, 5.22±0.27, all with significant difference(all P<0.05). The incidence of adverse drug reactions in treatment group and control group were 15.79%, 13.16%, without significant difference(P>0.05).Conclusion Baofukang gel in the treatment of elderly vaginitis can improve the clinical efficacy,and effectively regulate acid-base balance,and improve the vaginal cleanliness.